| 肝癌“双弹头”免疫导向药物的实验研究 |
| |
| 引用本文： | 刘利,隋延仿,陈志南,刘彦仿.肝癌“双弹头”免疫导向药物的实验研究[J].解放军医学杂志,1994(1). |
| |
| 作者姓名： | 刘利 隋延仿 陈志南 刘彦仿 |
| |
| 作者单位： | 第四军医大学病理教研室 |
| |
| 基金项目： | 国家“863”肝癌导向药物研究课题 |
| |
| 摘 要： | 以肝细胞癌单克隆抗体ＨＡｂ１８为载体，用葡聚糖作桥的间接交联方法和氯胺Ｔ法，同时将阿霉素（ＡＤＭ）和１３１Ｉ连接到ＨＡｂ１８上，制备出“双弹头”肝癌免疫导向药物１３１Ｉ－ＨＡｂ１８－ＡＤＭ。其免疫结合率为４３．５％。细胞毒实验结果显示，１３１Ｉ－ＨＡｂ１８－ＡＤＭ对靶肿瘤细胞ＳＭＭＣ－７７２１的杀伤效果较单独应用ＡＤＭ相同浓度的ＨＡｂ１８－ＡＤＭ和比放射性相同的１３１Ｉ－ＨＡｂ１８时，有明显的增强。１３１Ｉ－ＨＡｂ１８－ＡＤＭ具有选择性高效杀伤的作用，它集中了化疗与内放射治疗的优点，互相补充，展示了肿瘤导向治疗的良好前景。
|
| 关 键 词： | 单克隆抗体，阿霉素，碘－131，肝细胞瘤抗体－药物偶合物，治疗 |
THE STUDY OF "DOUBLE LABELING MISSILE" TARGETTING-DRUG FOR HEPA-TOCELLULAR CARCINOMA |
| |
| Liu Li,Sui Yanfang,Chen Zhinan,Liu Yanfang. Departrnent of Pathology,ForthMilitary Medical University. Xi'an.THE STUDY OF "DOUBLE LABELING MISSILE" TARGETTING-DRUG FOR HEPA-TOCELLULAR CARCINOMA[J].Medical Journal of Chinese People's Liberation Army,1994(1). |
| |
| Authors: | Liu Li Sui Yanfang Chen Zhinan Liu Yanfang Departrnent of Pathology ForthMilitary Medical University Xi'an |
| |
| Institution: | Liu Li,Sui Yanfang,Chen Zhinan,Liu Yanfang. Departrnent of Pathology,ForthMilitary Medical University. Xi'an,710032 |
| |
| Abstract: | Using the monoclonal antibody of hepatocellular carcinoma HAb18 as the carrier, isi I-HAb18-ADM was prepared by indirect conjugation with dextran and chloramine-T methods. The rate ofits immune combining power is 43. 5%. In vitro cytotoxyty study of 131I-HAb18-ADM showed a strongerselective cytotoxity against target tumor cells than HAb18-ADM or 131 I-HAb18. 131 I-HAb18-ADM hasthe advantage of a combination of chemotherapy and internal radiotherapy, thus exerting a berrer effect. |
| |
| Keywords: | Monoclonal antibody Adriamycin 131I Hepatocellular carcinoma Antibody-drug con-jugates Therapy |
| 本文献已被 CNKI 等数据库收录！ |
