| 子痫前期外周血免疫相关基因的差异表达 |
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| 引用本文： | 孙波,郑桂琴,赵卫华,高素清,张为远. 子痫前期外周血免疫相关基因的差异表达[J]. 浙江临床医学, 2009, 11(6): 570-572 |
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| 作者姓名： | 孙波 郑桂琴 赵卫华 高素清 张为远 |
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| 作者单位： | 1. 广东省深圳市第二人民医院妇产科,518035
2. 首都医科大学附属北京妇产医院,100026 |
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| 摘 要： | 目的 了解子痫前期患者外周血免疫相关基因的差异表达，探索其与子痫前期发病的关系。方法选择4例重度子痫前期患者为研究对象，以4例正常妊娠妇女为对照，应用基因芯片技术检测两组孕妇外周血差异基因表达谱，了解子痫前期外周血免疫相关基因的异常表达。结果在所检测的21000个基因中，出现2次重复一致差异表达的免疫相关基因共有33个，子痫前期组差异表达上调基因23个，下调基因10个。结论免疫相关基因的差异表达可能是子痫前期发病的原因之一。
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| 关 键 词： | 子痫前期 差异表达 寡核苷酸序列分析 基因 免疫 |
Differential expression of immunity-related genes in peripheral blood leucocytes in preeclampsia |
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| Abstract: | Objective To investigate the differential expression of immunity - related genes in peripheral blood leucocytes between preeelampsia and normal pregnancy cases, and to explore the pathogenesis of preeclampsia. Method The differential gene expression files of 4 severe preeclampsia and 4 normal pregnancy cases were studied using cDNA array technique in order to identify the differential expression of immunity - related genes. Results 33 differentially expressed immunity - related genes had the concordance in at least 2 cases among total 21000 genes. 23 genes were up - regulated and 10 were down - regulated. Conclusions Differential expression of immunity - related genes in peripheral leucocytes from preeclampsia may be responsible for the molecular mechanism of preeclampsia . |
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| Keywords: | Preeclampsia Differential expression Oligonucleotide array sequence analysis Gene Immunity |
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