骨髓单个核细胞抗人球蛋白分型试验在免疫相关性全血细胞减少症（IRP）中的诊断意义

本文研究骨髓单个核细胞抗人球蛋白分型试验在诊断免疫相关性全血细胞减少症（IRP）的临床意义。90例血细胞减少症患者入院后完善血清铁蛋白（SF），叶酸（FA）及维生素B12浓度，免疫学检查，血小板抗体，乙肝六项，甲肝及丙肝抗体、溶血相关检查、骨髓涂片及染色体核型分析等常规检查。实验组：28例拟诊免疫相关性全血细胞减少症。阳性对照组：自身免疫性溶血性贫血19例。阴性对照组：43例，包括再生障碍性贫血12例、骨髓增生异常综合征14例、巨幼细胞性贫血10例，阵发性睡眠型血红蛋白尿3例，缺铁性贫血4例。所有患者均进行骨髓单个核细胞抗人球蛋白分型试验。结果28例拟诊免疫相关性全血细胞减少症患者中13例骨髓单个核细胞抗人球蛋白试验阳性，阳性率为46．43％，抗体结合类型以IgG型最多见，I舭型较少。19例阳性对照组中仅2例骨髓单个核细胞抗人球蛋白分型试验阳性，阳性率为10．53％。43例阴性对照组中1例骨髓单个核细胞抗人球蛋白试验阳性，阳性率为2．33％。实验组骨髓单个核细胞分型试验阳性率显著高于阳性对照组及阴性对照组（P〈0．01）。结论骨髓单个核细胞抗人球蛋白分型试验为免疫相关性全血细胞减少症的诊断提供了一定的依据，并有利于制定更有效的治疗策略，而且为血细胞减少症的鉴别诊断提供了更多的检测手段。

The clinical meaning of the bone marrow mononuclearcell antihuman globulin blood grouping to diagnose the immunorelated pancytopenia(IRP)

Objective The objective was to explore Clinical Study of the bone marrow monounclearcell antihuman globulin blood grouping to diagnose the immunorelated pancytopenia. 90 pancytopeina patients have concentration test of serum ferritin, folic acid and vitB12,also have the immunologic test, test of Platelet antibody, test of type B and C hepatitis, the haemolysis test , bone marrow slides and chromosome karyotype analysis and some routine examinations. Experimental group： 28 patients considered to be immunorelated pancytopenia. Positive control group： 19 patients, were autoimmune hemolytic anemia. Negative control group：43 patients,of which 12 were aplastic anemia, 14 were myelodysplastic syndrome, 10 were megaloblastic anemia.3 were paroxysmal noc- turnal hemoglobinuria, 4 were iron deficiency anemia. All patients take the bone marrow mononuclearcell antihuman globulin blood grouping. Results Of all the 28 IRP patients, 13 were with bone marrow monounclearcell antihuman globulin blood grouping positive, with the positive ratio of 46.43 %, IgG type is the most common in the antibody fixation type, IgA is lesso Of the 19 positive con- trol group, only 2 with bone marrow mononuclearcell antihuman globulin blood grouping positive, with the positive ratio of 10.53 % o Of 43 negative control group, only 1 with bone marrow mononuclearcell antihuman globulin blood grouping positive, with the positive ratio of 2.33 % o The positive ratio of bone marrow mononuelearcell antihuman globulin blood grouping of experiment group is significant higher than positive control group or negative control group（ P 〈 0.01 ）. Conclusion the bone marrow mononuelearcell antihu- man globulin blood grouping offers determinate evidence in the diagnose of IRP, which also profit a better more effecive therapy strategy, meanwhile provide more test facility for diagnosis of cytopeniao