中晚期巨块型原发性肝癌的介入热化疗栓塞治疗

目的探讨介入热化疗栓塞（IHC）治疗巨块型原发性肝癌的疗效，并与经肝动脉化疗栓塞（TACE）进行对比。方法IHC治疗的中晚期巨块型原发性肝癌患者68例作为观察组，同期单纯行TACE治疗32例患者作为对照组。比较2组患者的疗效、生存质量、二次手术率、血清AFP下降程度、生存率及毒副作用。结果观察组有效率（79．4％）显著高于对照组（56．3％），P〈0．05。观察组经治疗后二次手术切除率（70．6％）显著高于对照组（43．8％），P〈0．01。观察组经治疗后Karnofsky评分增加20分以上者（35．3％）显著高于对照组（12．5％），P〈0．01；AFP下降程度大于50％者所占比例（52．9％）显著高于对照组（25．0％），P〈0．01。观察组术后12、18、24个月患者存活率均分别显著高于对照组（P〈0．01）。结论IHC治疗巨块型原发性肝癌疗效显著，可增加患者二次手术的机会，是治疗巨块型肝癌安全有效的治疗方式之一。

Interventional heated chemotherapy for moderate and advanced huge primary hepatocellular carcinoma

Objective To explore the effects of the therapeutic effects of interventional heated chemotherapy （IHC） for moderate and advanced huge primary hepatocellular carcinoma and compare with transcatheter arterial chemoembolization （TACE）. Methods The 68 pa-tients with moderate and advanced huge primary hepatocellular carcinoma accepted the treatment of IHC were considered as the observation group, and 32 patients managed TACE were regarded as the control group. The therapeutic effects, living quality, secondary surgery rates, The reduced level of serum AFP, survival rate, and toxic side effects of 2 groups were contrasted. Results The effective rate of observation group was obviously higher than that of control group （79.4% vs 56.3% , P 〈 0.05 ） , and secondary surgery rates was increased （70.6% vs 43.8% ,P 〈0.01 ）. The ratio of increased Karnofsky score was more than 20 in observation group,which was obviously higher than that of control group（35.3% vs 12.5% ,P 〈0.01 ）. T The reduced level of serum AFP was more than 50% in observation group,which was higher than that of control group （52.9% vs 25.0% ,P 〈 0. 01 ）. The survival rate of 12,18,24 months after treatment in control group was in- creased than that in control group individually （ P 〈 0.01 ）. Conclusion IHC is effective for huge primary hepatocellular carcinoma and in-creases the secondary surgery rates, which is one of the safe and effective methods for huge primary hepatocellular carcinoma.