HIV-1感染中的白介素-2免疫治疗作用

抗反转录病毒治疗（ART）开始的时机越来越早,但总有免疫重建失败或者Ⅰ型艾滋病病毒（HIV-1）潜伏感染灶无法清除的情况,因此白介素-2（IL-2）目前被广泛研究用于辅助ART治疗、加强免疫重建或者活化潜伏感染的HIV-1。目前比较确定的是：（1）IL-2能延长CD4＋T细胞的半衰期,增加CD4＋T细胞的数量;（2）IL-2合并ART与单独使用ART相比,不能减少HIV-1相关的机会性感染或死亡,临床应用着重于活化HIV-1储存库细胞;（3）IL-2合并ART能有效增加HIV-1储存库细胞的消减速率,外周循环中HIV-1感染的处于静止状态的记忆T细胞数量下降,甚至检测不出来;（4）IL-2的临床应用趋向周期性使用和长期使用。

Immuno-therapeutic effect of Interleukin-2 in HIV-1 infection

Antiretroviral therapy（ART）has been started in an increasingly earlier period in clinical practice.However,owing to the failure of immunological reconstitution or maintenance of latent HIV-1 reservoir in present antiviral treatment,interleukin-2（IL-2）is widely used as an adjuvant to ART with a view to intensifying immunological reconstitution and to activating latent HIV-1 infections.Some conclusions could be drawn as follows,1）IL-2 can extend the half-life of CD＋4 T cells and increase the number of CD＋4 T cells.2）Compared with ART alone,IL-2 and HAART combination can not reduce HIV-1 related opportunistic infection or death.IL-2 clinical usage is mainly focused on purging HIV-1 reservoir.3）IL-2 combined with ART could increase out flow rate of HIV-1 latent reservoir to reduce HIV-1 infected quiescent memory cells in peripheral circulation even to an undetectable level.4）IL-2 is supposed to be used periodically and for a long period of time.