盐酸氨基酮戊酸光动力疗法治疗尖锐湿疣临床观察 |
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引用本文: | 李军,刘永鑫,郑和义,米霞,刘秀荣. 盐酸氨基酮戊酸光动力疗法治疗尖锐湿疣临床观察[J]. 中国性病艾滋病防治, 2010, 0(6): 585-586,598 |
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作者姓名: | 李军 刘永鑫 郑和义 米霞 刘秀荣 |
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作者单位: | [1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730 [2]北京世纪坛医院皮肤科,北京100038 |
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摘 要: | 目的评价盐酸氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣的疗效。方法使用ALA治疗127例尖锐湿疣患者(试验组),采用液氮冷冻治疗47例尖锐湿疣患者(对照组)。结果入组的174例尖锐湿疣患者中,经过ALA-PDT治疗和液氮冷冻治疗,1周后痊愈率分别为73.23%和53.19%;治疗2周后,二组的痊愈率分别为85.83%和63.83%(P〈0.01);治疗3周后,二组的痊愈率分别为93.70%和70.21%(P〈0.01)。试验组的总复发率为10.17%(6/59),明显低于对照组45.45%(15/33)的总复发率。结论外用ALA-PDT疗法治疗尖锐湿疣治愈率高,复发率低。
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关 键 词: | 尖锐湿疣 氨基酮戊酸 光化学疗法 冷冻治疗 |
A clinical observation of aminolevulinic acid photodynamic therapy for condyloma acuminatum |
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Affiliation: | LI Jun,LIU Yong-Xin,ZHENG He-Yi,et al.(Department of Dermatology and Venereology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China) |
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Abstract: | Objective To evaluate the efficiency of topical 5-aminolevulinic acid photodynamic therapy(ALA-PDT) in the treatment of condyloma acuminatum(CA).Methods Patients with condyloma acuminatum were assigned to the ALA-PDT group and the cryotherapy group(control)(127 in the ALA-PDT group and 47 in the control group).Results A total of 174 patients with condyloma acuminatum were enrolled in the clinical tria1.One week after the treatment,53.19% and 73.23% of the base line warts were eliminated totally in the control group and the ALA-PDT group,respectively.At 2 weeks after the treatment,complete remission was 63.83% for the cryotherapy group and 85.83% for the ALA-PDT group,respectively(P0.01).At 3 weeks after the treatment,93.70% and 70.21% of the base line warts were eliminated in the ALA-PDT group and the control group,respectively(P0.01).Furthermore,the overall relapse rate in ALA-PDT group was 10.17%(6/59),which was significantly lower than that in cryotherapy group(15/33,45.45%).Conclusion Compared with cryotherapy,ALA-PDT has the advantages of a higher therapeutic efficacy and a lower relapse rate. |
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Keywords: | Condylomata acuminatum Aminolevulinic acid Photochemotherapy Cryotherapy |
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