| 胃癌活组织c—erb—B2过度表达与预后的关系 |
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| 引用本文： | 季峰 彭清壁. 胃癌活组织c—erb—B2过度表达与预后的关系[J]. 中华消化内镜杂志, 1997, 14(5): 295-297 |
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| 作者姓名： | 季峰 彭清壁 |
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| 作者单位： | 浙江医科大学附属第一医院消化内科，浙江医大病理教研室，美国西雅图华盛顿大学医学部生物中心 |
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| 基金项目： | 浙江省科委自然科学基金 |
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| 摘 要： | 探讨胃癌活检组织ｃ－ｅｒｂ－Ｂ２过度表达与预后的关系。用免疫组化法检测１０３例胃癌胃镜活检组织及术后１５１个转移淋巴结ｃ－ｅｒｂ－Ｂ２表达。结果：１８．４％胃癌活检组织出现阳性表达，进展期胃癌、乳头状腺癌及伴淋巴与肝转移者阳性率增高（Ｐ均＜０．０５）；阳性表达更多见于高中分化胃癌（但Ｐ＞０．０５）；转移淋巴结表达阳性率高于胃癌原发病灶（Ｐ＜０．０５）。高中分化胃癌ｃ－ｅｒｂ－Ｂ２过度表达者５年生存率低于阴性者（Ｐ＜０．０１）。以上结果提示ｃ－ｅｒｂ－Ｂ２过度表达与否有助于胃癌预后的估计。
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| 关 键 词： | 胃癌 c－erb－B_2 过度表达 预后 |
CORRELATION BETWEEN OVEREXPRESSION OF C erb B 2 PROTEIN AND PROGNOSIS IN GASTRIC CARCINOMA |
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| Ji Feng,Peng Qingbi,Zhu Youfa,et al.. CORRELATION BETWEEN OVEREXPRESSION OF C erb B 2 PROTEIN AND PROGNOSIS IN GASTRIC CARCINOMA[J]. Chinese Journal of Digestive Endoscopy, 1997, 14(5): 295-297 |
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| Authors: | Ji Feng Peng Qingbi Zhu Youfa et al. |
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| Affiliation: | Ji Feng,Peng Qingbi,Zhu Youfa,et al.First Affiliated Hospital of Zhejiang Medical Univrsiey,Hangzhou 310003 |
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| Abstract: | Immunohistochemical reactivity of oncoprotein c erb B 2 was assayed in 103 endoscopic tissue biopsies and 151 resected lymph nodes to clarify its significance in gastric cancer prognosis.Results revealed that expression of C erb B 2 was positive in 18 45% of bioptic tissues;the rate of positive reaction increased in papillary adenocarcinomas,advanced cancers and those with lymphatic and hepatic metastasis( P <0 05 in all cases);positive reactivity in metastatic nodes expressed higher than in primary lesions( P <0 05);5 year survival rate in patients with well differentiated gastric cancer and overpression of C erb B 2 seemed lower than that with negative expression( P <0 01). |
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| Keywords: | Gastric carcinoma C erb B 2protein Overexpression Prognosis |
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