BRAF mutations might be more common than supposed in vulvar melanomas |
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| Authors: | Sophie Wylomanski Marc G. Denis Sandrine Théoleyre Réjane Bouquin Audrey Vallée Anne‐Chantal Knol Mélanie Saint‐Jean Lucie Peuvrel Brigitte Dréno Gaëlle Quéreux |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Nantes University Hospital, Nantes, France;2. INSERM U 1232, Nantes, France;3. Department of Biochemistry, Nantes University Hospital, Nantes, France;4. Immuno‐Dermatology Laboratory, Nantes University Hospital, Nantes, France;5. Department of Dermatology, Nantes University Hospital, Nantes, France;6. INSERM CIC 1413, Clinical Investigation Center, Nantes University Hospital, Nantes, France |
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| Abstract: | Data on BRAF, NRAS and KIT mutations are scarce in patients with vulvo‐vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7%) harboured a BRAF mutation, which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a NRAS mutation in a cutaneous metastasis. Our data provide a rationale for prospective and repeated mutations testing in female lower genital tract melanomas. |
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| Keywords: | female lower genital tract melanoma oncogenic mutations |
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