A dipeptidyl peptidase‐4 inhibitor promotes wound healing in normoglycemic mice by modulating keratinocyte activity |
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| Authors: | Chun‐Ming Shih Chun‐Yao Huang Chien‐Yu Huang Kuo‐Hsien Wang Po‐Li Wei Yu‐Jia Chang Tsorng‐Harn Fong Jun‐Liang Pan Ai‐Wei Lee |
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| Affiliation: | 1. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;2. Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan;3. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;4. Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;5. Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan;6. Graduate Institute of Cancer Biology and Drug Discovery, Graduate Institute of Clinical Medicine, Taipei, Taiwan;7. Division of General Surgery, Department of Surgery, Cancer Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan;8. Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan |
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| Abstract: | Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are a well‐known and novel class of oral antihyperglycaemic drugs. DPP‐4 inhibition facilitates ulcer healing in patients with diabetes. However, the actual mechanisms, which are independent of lower blood glucose levels, are still unknown. Therefore, the aim of this study was to analyse the effect of the DPP‐4 inhibitor sitagliptin on wound healing through a glucose‐independent pathway. In this study, DPP‐4 inhibitors facilitate keratinocyte differentiation and the proliferation, increase blood flow in the cutaneous of wounds in healthy C57BL/6 mice. Additionally, the administration of the DPP‐4 inhibitor ameliorates wound healing and enhances adiponectin expression in healthy C57BL/6 mice. Taken together, our results reveal a protective role for the DPP‐4 inhibitor sitagliptin in wound healing by regulating adiponectin and phospho‐eNOS levels in keratinocytes. Based on these results, the DPP‐4 inhibitor may have therapeutic potential for healing wounds through a diabetes‐independent mechanism. |
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| Keywords: | dipeptidyl peptidase‐4 keratinocyte wound healing |
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