Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis |
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Authors: | Xia Hong Shan Jiang Nancy Marmolejo Ramya Vangipuram Elmira Ramos‐Rojas Yulin Yuan Zuan‐Tao Lin Yaxi Li Jingyi Qiu Yikun Xing Christopher Haley Stephen K Tyring Tianfu Wu |
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Institution: | 1. Department of Nursing, Fujian Health College, Fuzhou, China;2. Department of Biomedical Engineering, University of Houston, Houston, Texas;3. Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China;4. Center for Clinical Studies, Webster, Texas;5. Department of Dermatology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas;6. Department of Clinical Laboratory, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China |
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Abstract: | To discover novel biomarkers of psoriasis, a target‐specific antibody array screening of serum samples from psoriasis patients was initially performed. The results revealed that vascular endothelial growth factor receptor 3 (VEGFR‐3) was significantly elevated in the sera of psoriasis patients, compared to healthy controls. Next, ELISA validation studies in a larger cohort of psoriasis patients (N = 73) were conducted, which confirmed that serum VEGFR‐3 was indeed significantly increased in patients with psoriasis compared to healthy controls (P < 0.001). Furthermore, receiver operating characteristic curve analysis demonstrated that serum VEGFR‐3 exhibited potential in distinguishing healthy controls from psoriasis patients: area under the curve = 0.85, P < 0.001. In addition, serum levels of VEGFR‐3 were correlated with Psoriasis Area Severity Index scores (R = 0.32, P = 0.008) in psoriasis patients. Interestingly, serum VEGFR‐3 levels were significantly elevated in psoriatic arthritis compared to non‐psoriatic arthritis (P = 0.026). A pilot longitudinal study demonstrated that serum levels of VEGFR‐3 could reflect disease progression in psoriasis. Collectively, serum VEGFR‐3 may have a clinical value in monitoring disease activity of psoriasis. |
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Keywords: | biomarker psoriasis vascular endothelial growth factor receptor 3 |
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