制粒技术在药物掩味方面的研究进展

在常用的口服固体制剂中,口感不良会导致患者对药物的依从性差,进而使得该药物的市场竞争力降低。药物制剂的掩味问题一直是制剂学面临的重要问题之一,随着人们对药物口感的要求日渐提升,近几年掩盖药物不良口味的方法也逐渐增加。通过对掩盖药物不良口味的相关文献进行总结,常用的掩味技术有添加掩味剂、包合技术、微球/微囊技术、固体分散技术、离子交换技术等。然而,除以上掩味技术之外,在固体制剂的制造过程中,制粒技术也可以实现对药物不良口味的遮蔽,且制粒技术方法简单,能够很好地达到掩盖药物不良口味的效果,该文系统介绍了制粒技术在药物掩味方面的研究进展,以期为药物掩味技术的选择提供参考。随着人们对药物口感的需求逐渐提高,药物掩味技术越来越受到广大制剂工作者的重视,但目前仍然存在一些问题,如口感评价体系不完善、方法特异性较低等,这一系列的问题均有待于相关药学工作者进一步研究和解决。

Research Progress of Granulation Technology for Taste Masking of Pharmaceutical Preparation

In commonly used oral solid preparations, poor mouthfeel results in poor patient compliance with the drug, which in turn reduces the market competitiveness of the drug. The problem of taste masking of pharmaceutical preparations has always been one of the important problems faced by pharmaceutics. With the increasing demand for the taste of drugs, the methods of masking bad taste of drugs have gradually increased in recent years. By summarizing the relevant literature covering the bad taste of drugs, the commonly used taste masking techniques include the addition of taste masking agents, inclusion techniques, microsphere/microcapsule technology, solid dispersion technology, ion exchange technology and the like. However, in addition to the above taste masking techniques, in the manufacturing process of the solid preparation, the granulation technique also can achieve the shielding of the bad taste of the medicine, and the granulation technique is simple, and can well achieve the effect of masking the bad taste of the medicine. This paper systematically introduces the research progress of granulation technology in drug taste masking, in order to provide reference for the selection of drug taste masking technology. With the increasing demand for drug taste, drug masking technology has been paid more and more attention by the majority of preparation workers, however, there are still some problems, such as imperfect taste evaluation system and low specificity of methods. This series of problems need to be further studied and solved by relevant pharmaceutical researchers.