| 机械敏感性离子通道Piezo2的研究进展 |
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| 引用本文： | 徐曼秋,费素娟. 机械敏感性离子通道Piezo2的研究进展[J]. 安徽医药, 2019, 23(2): 217-220 |
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| 作者姓名： | 徐曼秋 费素娟 |
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| 作者单位： | 徐州医科大学消化内科实验室,江苏 徐州,221000;徐州医科大学消化内科实验室,江苏 徐州,221000 |
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| 摘 要： | Piezo2是将小核糖核酸干扰技术应用于小鼠Neuro2A细胞系而发现的一种新型机械力敏感非选择性阳离子通道。其对阳离子的渗透率为Ca2+>K+>Na+>Mg2+。它能够感受机械刺激并将其转化为电信号,参与轻触觉、本体感觉、机械性痛觉超敏、肿瘤血管生成等多种病理生理过程。该文现就Piezo2的结构、调节、功能等进行综述。
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| 关 键 词： | Piezo2 本体感觉 轻触觉 疼痛 肿瘤 |
| 收稿时间： | 2017-05-18 |
| 修稿时间： | 2017-07-01 |
Research progress of mechanosensitive ion channel Piezo2 |
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| XU Manqiu and FEI Sujuan. Research progress of mechanosensitive ion channel Piezo2[J]. Anhui Medical and Pharmaceutical Journal, 2019, 23(2): 217-220 |
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| Authors: | XU Manqiu and FEI Sujuan |
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| Affiliation: | Laboratory of Gastroenterology,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China and Laboratory of Gastroenterology,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China |
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| Abstract: | Piezo2 is a novel mechanosensitive non-selective cation channel discovered by applying small RNA interference technology to mouse Neuro2A cell line.The rank order of its permeability to cations is Ca2+>K+>Na+>Mg2+.Piezo2 is responsible for the perception of mechanical stimulus and then transfers them into electrical signals.This channel plays an important role in many pathophysiological processes,such as light touch,proprioception,mechanical allodynia,tumor angiogenesis and so on.This review summarizes the current knowledge on Piezo2 structure,regulation,function,etc. |
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| Keywords: | Piezo2 Proprioception Light touch Pain Tumor |
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