不同部位骨质疏松骨折女性患者肌肉减少症的患病率及相关危险因素分析

目的研究不同骨折部位骨质疏松女性患者肌肉减少症的患病率,并探索骨质疏松性骨折并发肌肉减少症的相关危险因素。方法共有112名50岁以上患有骨质疏松性骨折(髋、脊柱或腕)的患者纳入本研究。使用双能X线吸收仪检测患者的骨密度和肌肉量。Logistic回归分析用于分析骨质疏松性骨折合并肌肉减少症的危险因素。结果 2015年4月至2017年8月期间112例女性骨质疏松性骨折患者中,42例(37.5%)确诊为肌肉减少症,髋部骨折41.8%(18/43),脊柱骨折36.7%(15/41),桡骨远端骨折32.1.6%(9/28)。各组之间的体质指数(BMI,P=0.005)、慢性肾病(CKD,P=0.002)和类风湿性关节炎(P=0.001)的患病率差异有统计学意义。在Logistic多变量回归分析中,BMI,CKD和RA与肌肉减少症风险增加相关。结论根据骨折部位评估了骨骼肌减少症的患病率,并确定了骨质疏松性骨折出现肌肉减少症的相关危险因素为BMI,CKD和RA。

Prevalence of sarcopenia in women with osteoporosis at different fracture sites and analysis of the related risk factors

Objective To determine the prevalence of sarcopenia according to fracture sites and to evaluate the associated risk factors in female patients with osteoporotic fractures. Methods A total of 112 patients aged 50 years or older with an osteoporotic fracture (hip, spine, or wrist) were enrolled in this study. A diagnosis of sarcopenia was confirmed using whole-body densitometry for skeletal muscle mass measurement. Logistic regression analysis was used to analyze the risk factors for sarcopenia. Results Of 112 female patients treated for osteoporotic fractures between April 2015 and August 2017, sarcopenia was diagnosed in 42 cases (37.5%). Among those, 41.8% (18/43) had hip fractures, 36.7% (15/41) had spine fractures, and 32.1.6% (9/28) had distal radius fractures. Body mass index (BMI; P=0.005) and prevalence of chronic kidney disease (CKD; P=0.002) and rheumatoid arthritis (P=0.001) were significantly different between the groups. In multivariable analysis, BMI, CKD, and RA were associated with an increased risk of sarcopenia, and there were statistically significant differences (P<0.05). Conclusion This study evaluated the prevalence of sarcopenia according to the fracture site and identified associated risk factors such as BMI, CKD, and RA in patients with osteoporotic fractures.