注射用丹参多酚酸治疗颈内动脉系统脑梗死的临床疗效及对血液指标影响

目的 研究颈内动脉系统脑梗死患者给予注射用丹参多酚酸治疗的临床疗效，及其对血液指标的影响。方法 从保定市第一中心医院2016年1月1日-2017年6月1日收治的颈内动脉系统脑梗死患者中选取100例作为研究对象，随机分为2组，各50例。对照组给予常规治疗，观察组在常规治疗基础上给予注射用丹参多酚酸130 mg溶于250 mL 0.9%氯化钠注射液中静脉滴注，1次/d，均14 d为1个疗程。比较治疗后两组患者的疗效、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、D-二聚体（D-D）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、总胆固醇（TC）、C反应蛋白（CRP）、同型半胱氨酸（Hcy）、基质金属蛋白酶9（MMP9）、白介素-6（IL-6）等指标的变化。结果 治疗后观察组总有效率88.00%显著高于对照组76.00%，差异有统计学意义（P<0.05）。观察组Hcy、CRP、FIB、D-D、LDL-C、TG、TC、IL-6、MMP9均显著低于对照组，差异有统计学意义（P<0.05）；观察组HDL-C显著高于对照组，差异有统计学意义（P<0.05）。观察组不良反应总发生率12.00%与对照组不良反应总发生率14.00%无明显差异。结论 注射用丹参多酚酸治疗颈内动脉系统脑梗死疗效显著，并可有效改善血脂、血凝情况，降低炎性因子水平，且安全性好。

Clinical effect of Salvianolic Acids for Injection on cerebral infarction in carotid artery system, itssecurity analysis and effect on blood indexes

Objective To study the clinical efficacy of Salvianolic Acids for Injection (SAFI) on cerebral infarction in the carotid artery system, and evaluate its safety and effects on blood indexes. Methods A total of 100 cases of carotid artery systemcerebral infarction patients in Baoding No.1 Central Hospital from January 1st, 2016 to June 1st, 2017 were selected as the research object, patients were randomly divided into two groups, 50 cases in the control group were given routine treatment, 50 cases in the observation group were given SAFI 130 mg of which was dissolved in 250 mL of 0.9% sodium chloride injection, and intravenous infusion was given once a day, for 14 d as one course. After treatment, curative effect, blood lipid, blood coagulation, C reactive protein (CRP), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dinmei (D-D), LDL cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), homocysteine (Hcy), MMP9 (matrix metalloproteinase 9) and IL-6 (interleukin-6) of the two groups were compared. Results After treatment, the total effective rate of the observation group 88% was significantly higher than that of the control group 76% (P<0.05). There was no significant difference between PT, APTT of the observation group and the control group (P>0.05); Hcy, CRP, FIB, D-D, LDL-C, TG, TC, IL-6, and MMP9 of the observation group were significantly lower than those of the control group (P<0.05); HDL-C of the observation group were significantly higher than those of the control group (P<0.05). There had no significant difference between total incidences of adverse reactions of the observation group 12% and the control group 14%. Conclusion The SAFI for the treatment of cerebral infarction of internal carotid artery system has significant curative effect, and can effectively improve blood lipid, blood coagulation situation, reduce levels of inflammatory factors, and show good safety.