速效救心丸干预气滞血瘀型急性冠脉综合征患者血管重建术后的疗效观察

[目的]观察速效救心丸对气滞血瘀型急性冠脉综合征(ACS)经皮血管重建术后患者的干预作用。[方法]采用随机、双盲、安慰剂对照方法,纳入58例接受血管重建术治疗的气滞血瘀型ACS患者,且辨证为气滞血瘀证型,随机分为对照组和治疗组,每组各29例,在标准化西医药物治疗基础上,对照组加予安慰剂,治疗组加予速效救心丸,干预6个月后,记录治疗前后患者的心绞痛积分、中医证候积分、左室射血分数和冠脉造影结果。评价速效救心丸疗效。[结果]治疗6个月后,与治疗前比较,两组心绞痛积分,中医证候积分,左室射血分数(LVEF)均有明显改善(P0.01),且治疗组改善更明显(P0.01)。治疗后复查冠脉造影,治疗组无支架再狭窄,对照组发生支架内再狭窄1例。治疗后患者安全性指标未见明显异常。[结论]速效救心丸的联合干预可更好的改善ACS血管重建术后患者气滞血瘀症状和左室射血分数,增加疗效且无明显不良反应。

Effects on SuxiaoJiuxin pills in the treatment of qi stagnation and blood stasis type patients with acute coronary syndromes undergoing early percutaneous coronary intervention

[Objective] To observe the effect of SuxiaoJiuxin pills on qi stagnation and blood stasis type patients with ACS coronary revascularization.[Methods] By the method of random, double blindness and placebo control, we enrolled 58 ACS patients with qi stagnation and blood stasis. They were randomly divided into control group and treatment group, 29 cases in each group. On the basic western medicine treatment, control group received placebo and treatment group received Suxiaojiuxin pills. After 6 month intervention, agiogram were test to value the effect of Suxiaojiuxin pills.[Results] After 6 month treatment, angina pectoris symptom scores, TCM symptom scores and LVEF were all ameliorated in both the control and treatment group (P<0.01), and more significant in latter group. The in-stent restenosis occurred in 1 case in control group, but none in treatment group, in the coronary re-angiogram after treatment. Safety index were negative in both group.[Conclusions] The combination of SuxiaoJiuxin pills could significantly improve qi stagnation and blood stasis symptoms of ACS patients and improve the left ventricular systolic function, without obvious side effect.