| Seldinger法区域动脉乌司他丁灌注联合奥曲肽治疗重症急性胰腺炎的疗效及其机制 |
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| 引用本文： | 濮娜.Seldinger法区域动脉乌司他丁灌注联合奥曲肽治疗重症急性胰腺炎的疗效及其机制[J].内科急危重症杂志,2019,25(5):378-380. |
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| 作者姓名： | 濮娜 |
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| 作者单位： | 沈阳市第四人民医院 |
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| 摘 要： | 目的:探讨Seldinger法区域动脉乌司他丁灌注联合奥曲肽对重症急性胰腺炎(SAP)患者血清Ghrelin、巨噬细胞炎性蛋白-1α(MIP-1α)、巨噬细胞炎性蛋白-1β(MIP-1β)水平的影响及临床疗效。方法:将132例SAP患者按照随机数字表法,分为观察组(乌司他丁+奥曲肽)和对照组(奥曲肽),每组66例。比较2组的临床疗效和血清中C反应蛋白(CRP)、白介素-6(IL-6)以及Ghrelin、MIP-1α、MIP-1β水平,并分析2组并发症发生率及病死率。结果:观察组治疗有效率高于对照组(80.3%vs 60.6%,P0.05),且在腹痛缓解时间、首次排便时间、胃肠减压时间及住院时间上均短于对照组(均P0.05);治疗7 d后,2组血清中CRP、IL-6、Ghrelin、MIP-1α、MIP-1β水平均较治疗前明显下降,且观察组均低于对照组(P0.05);观察组急性肾衰竭、急性呼吸窘迫综合征、休克及病死率均低于对照组(均P0.05)。结论:应用Seldinger法区域动脉乌司他丁灌注联合奥曲肽治疗SAP患者,有利于抑制Ghrelin、MIP-1α、MIP-1β表达,抑制炎症反应,提高临床疗效。
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| 关 键 词： | miR-126 冠状动脉粥样硬化性心脏病 稳定型心绞痛 急性冠状动脉综合征 |
Efficacy and anti inflammatory mechanism of eustatin combined with octreotide in the treatment of severe acute pancreatitis with Seldinger method |
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| YANG Wang,YIN-jun Li,XING Yun-yun and LI Xin.Efficacy and anti inflammatory mechanism of eustatin combined with octreotide in the treatment of severe acute pancreatitis with Seldinger method[J].Journal of Internal Intensive Medicine,2019,25(5):378-380. |
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| Authors: | YANG Wang YIN-jun Li XING Yun-yun and LI Xin |
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| Institution: | Department of Cardiovascular Diseases, Shenyang Fourth People''s Hospital |
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