胞磷胆碱联合普罗布考治疗急性脑梗死的疗效观察

目的研究胞磷胆碱钠胶囊联合普罗布考片治疗急性脑梗死的临床疗效。方法选取2015年12月—2017年12月十堰市人民医院收治的急性脑梗死患者100例为研究对象,所有患者随机分为对照组和治疗组,每组各50例。对照组患者每日早晚餐时口服普罗布考片,1片/次,2次/d。治疗组患者在对照组治疗的基础上口服胞磷胆碱钠胶囊,2粒/次,3次/d。两组患者持续治疗6个月。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活活动量表(ADL)评分、血脂水平。结果治疗后,对照组和治疗组的总有效率分别为82.00%、96.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者的NIHSS评分显著下降,ADL评分显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组NIHSS评分和ADL评分明显优于对照组,同组治疗前后比较差异有统计学意义(P0.05)。治疗后,两组患者总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平明显下降,低密度脂蛋白胆固醇(LDL-C)水平显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组血脂水平明显优于对照组,同组治疗前后比较差异有统计学意义(P0.05)。结论胞磷胆碱钠胶囊联合普罗布考片治疗急性脑梗死具有较好的临床疗效,可改善患者神经功能损伤和生活质量,降低患者血脂水平,安全性较好,具有一定的临床推广应用价值。

Clinical observation of citicoline combined with probucol in treatment of acute cerebral infarction

Objective To study the clinical effect of Citicoline Sodium Capsules combined with Probucol Tablets in treatment of acute cerebral infarction. Methods Patients (100 cases) with acute cerebral infarction in Shiyan People''s Hospital from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Probucol Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Citicoline Sodium Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 96.00%, respectively, and there was difference between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, but ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of TC, TG, and HDL-C in two groups were significantly decreased, but the levels of LDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Citicoline Sodium Capsules combined with Probucol Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve neurological impairment and quality of life, reduce blood lipid level, with good safety, which has a certain clinical application value.