注射用丹参多酚酸治疗急性脑梗死的临床疗效观察

目的 观察注射用丹参多酚酸治疗急性脑梗死的临床疗效。方法 选择发病时间在72 h内的急性脑梗死住院患者100例，随机分为观察组和对照组，每组50例。对照组给予抗血小板聚集、清除自由基等常规治疗，观察组在对照组治疗基础上给予注射用丹参多酚酸130 mg，溶于0.9%氯化钠注射液250 mL中静脉滴注，1次/d，两组均治疗14 d。治疗前后分别采用欧洲卒中分量表神经功能评分（ESS）和日常生活能力评分（Barthel ADL指数）进行判定，对两组的临床疗效进行比较。结果 治疗2周后，观察组总有效率90.0%，高于对照组的76.0%，两组比较差异有统计学意义（P<0.05）；观察组与对照组的ESS评分和Barthel ADL指数较治疗前均有改善，差异有统计学意义（P<0.05），且观察组的优于对照组的（P<0.05）。结论 注射用丹参多酚酸对改善急性脑梗死患者的行为障碍和神经症状有较好的疗效。

Clinical efficacy of Salvianolic Acids for Injection in treatment of acute cerebral infarction

Objective To observe the clinical effect of Salvianolic Acids for Injection (SAFI) in treatment of acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction and the onset time within 72 h, were randomly divided into the treatment group and the control group, 50 cases in each group.The control group was given routine treatment such as antiplatelet aggregation and free radical scavenging. The observation group was given 130 mg SAFI dissolved in 0.9% sodium chloride injection 250 mL by intravenous drip once a day based on the treatment of the control group. Patients in the both groups were treated for 14 d. Before and after treatment with the European stroke subscales neurologic evaluation (ESS) score and daily activity score (Barthel ADL index) were used to determine the clinical efficacy of the two groups. Results After two weeks of treatment, the total effective rate was 90.0% in the treatment group and 76.0% in the control group. The difference between the two groups was statistically significant (P<0.05). The improvement of ESS score and Barthel ADL index in two groups were better than those before treatment (P<0.05), and treatment groups were better than those in control groups (P<0.05). Conclusion SAFI has a good effect on improving behavioral disorder and neurological symptoms in patients with acute cerebral infarction.