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中药材中黄曲霉毒素的防控措施研究进展
引用本文:李婷,胡小松,巩颖,付闪雷,王龙,华国栋,刘春生.中药材中黄曲霉毒素的防控措施研究进展[J].中国实验方剂学杂志,2019,25(7):228-234.
作者姓名:李婷  胡小松  巩颖  付闪雷  王龙  华国栋  刘春生
作者单位:北京中医药大学 中药学院, 北京 100029,北京中医药大学 中药学院, 北京 100029,北京中医药大学 东方医院, 北京 100078,北京科园信海医药经营有限公司, 北京 100160,北京科园信海医药经营有限公司, 北京 100160,北京中医药大学 东方医院, 北京 100078,北京中医药大学 中药学院, 北京 100029
基金项目:国家公益性科研专项(201507002);北京科园信海医药经营有限公司-北京中医药大学横向课题-冷链储藏条件下种子类药材的质量和安全性研究(2018110031002524)
摘    要:中医药受到国际社会越来越多的关注,世界范围内对中医药的需求日益增长,潜在的中药质量安全隐患也日渐突出。黄曲霉毒素污染是影响中药材安全问题的重要因素之一,目前已有多种方法被用于减少或降低黄曲霉毒素,然而很少有合适方法能在中药材中经济、高效、大规模的推广与应用。因此,继续研究解决黄曲霉菌及其毒素污染问题的措施有着非常重要的意义。该文通过对黄曲霉毒素的危害及污染现状、防控黄曲霉菌生长及降解黄曲霉毒素的措施进行综述,并对未来防控黄曲霉菌及其毒素的前景进行展望,旨在为解决黄曲霉菌及其毒素污染问题提供思路,以保证中药材质量,从而确保临床用药的安全有效。

关 键 词:黄曲霉毒素  预防与控制  中药材  安全性  黄曲霉菌  微生物  降解
收稿时间:2018/6/23 0:00:00

Research Progress on Prevention and Control Measures of Aflatoxin in Chinese Medicinal Materials
LI Ting,HU Xiao-song,GONG Ying,FU Shan-lei,WANG Long,HUA Guo-dong and LIU Chun-sheng.Research Progress on Prevention and Control Measures of Aflatoxin in Chinese Medicinal Materials[J].China Journal of Experimental Traditional Medical Formulae,2019,25(7):228-234.
Authors:LI Ting  HU Xiao-song  GONG Ying  FU Shan-lei  WANG Long  HUA Guo-dong and LIU Chun-sheng
Institution:School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China,Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China,Beijing Kyuan Xinhai Pharmaceutical Co. Ltd., Beijing 100160, China,Beijing Kyuan Xinhai Pharmaceutical Co. Ltd., Beijing 100160, China,Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China and School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
Abstract:At present,traditional Chinese medicine(TCM) has attracted more and more attention from the international community.The demand for TCM is increasing in the world.The hidden dangers of potential quality and safety of TCM are also becoming increasingly prominent.Aflatoxin contamination has become one of the important factors affecting the safety of Chinese herbal medicines,and it will fundamentally affect human health and life safety.A variety of methods are used to reduce aflatoxins,however,there are few suitable methods that can be widely used in the cost-effective and large-scale promotion of Chinese herbal medicines.Therefore,it is of great significance to continue to study measures to solve the pollution problems of Aspergillus flavus and its toxins.This article summarizes the hazards and contamination status of aflatoxin,the prevention and control of the growth of A. flavus, and the measures for reducing aflatoxin,and looks ahead to the future prevention and control of A. flavus and its toxins,aiming at providing ideas for the pollution problem of A. flavus and its toxin,to ensure the quality of Chinese herbal medicines,so as to ensure clinical safety medication.
Keywords:aflatoxin  prevention and control  Chinese herbal medicines  security  Aspergillus flavus  microbes  degradation
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