郁金及其近缘药材的研究进展及质量标志物(Q-marker)的预测分析

郁金为多基原药材,与莪术、姜黄和片姜黄都来源于姜科姜黄属植物,并且基原之间各有交叉,但在入药部位、炮制方法上各有不同;在传统功效上同为辛、苦味,兼具活血和行气之功,但又有各自的特点和功效倾向。因此,对于这"一组"近缘中药,建立能够反映共同特点和差异性特征的质量评价方法和质量控制体系具有重要意义。在梳理传统文献及总结现代研究报道的基础上,根据中药质量标志物(Q-marker)的概念与核心理论,提出以"基原-炮制-药用部位"为基点的成分特有性、以"药效-药性-新临床用途"为基点的有效性的Q-marker研究思路和方法,对郁金类药材Q-marker进行预测分析。

Research progress on Curcumae Radix and its near-source species and predictive analysis on Q-marker

Curcuma Radix is a kind of multi-base crude drug, which is originated from Curcuma genus same as Curcuma longa, Curcumae Rhizoma, and Wenyujin Rhizoma Concisum. There are original overlapping parts among them, but in the part of medicine and the processing method are different. In the traditional efficacy, the flavors of them are both spice and bitter, with the same effects of moving qi and activating blood flow, they also have their own characteristics and efficacy tendency. Therefore, it is of special significance to establish the quality evaluation method and quality control system which can reflect the common characteristics and the differences between Curcumae Radix and its near-source species. On the basis of combing the traditional literatures and summing up the modern research reports, according to the concept and core theory of quality marker of traditional Chinese medicine, this paper puts forward the research ideas and methods about characteristics of components based on "origin-processing-medicinal parts" and component validity based on "medicinal efficacy-medicinal property-new clinical use" to predict and analyze the quality marker of Curcumae Radix.