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| 闭角型青光眼患者红细胞免疫功能与EPO和ET-1的相关性 | |
| 引用本文： | 张郧芳,郭蕊,刘永丽,潘桂萍. 闭角型青光眼患者红细胞免疫功能与EPO和ET-1的相关性[J]. 国际眼科杂志, 2019, 19(3): 422-425 |
| 作者姓名： | 张郧芳 郭蕊 刘永丽 潘桂萍 |
| 作者单位： | 中国湖北省十堰市太和医院眼科,中国湖北省十堰市太和医院眼科,中国湖北省十堰市太和医院眼科,中国湖北省十堰市太和医院眼科 |
| 摘 要： | 目的：探讨闭角型青光眼患者红细胞免疫功能与血清促红细胞生成素(EPO)和血浆内皮素-1(ET-1)的相关性。 方法：选取2017-06/10期间我院收治的闭角型青光眼患者30例(病例组)与眼部正常者30例(对照组)为研究对象。测定并比较两组受试者红细胞免疫功能、血清EPO和血浆ET-1浓度，分析之间的相关性。 结果：病例组受试者红细胞C3b受体花环率明显低于对照组(10.81%±2.01% vs 18.06%±3.44%)，红细胞免疫复合物花环率明显高于对照组(17.21±3.49% vs 11.74±2.14%)，血清EPO浓度明显高于对照组(26.10±5.22 mU/mL vs 22.68±4.06mU/mL)，血浆ET-1浓度明显高于对照组(70.85±7.16ng/L vs 58.43±5.09ng/L)。闭角型青光眼患者红细胞C3b受体花环率与血清EPO浓度呈显著正相关(r=0.271，P<0.05)，与血浆ET-1浓度无明显相关性。 结论：闭角型青光眼患者红细胞免疫功能与血清EPO浓度呈正相关。 |
| 关 键 词： | 闭角型青光眼 免疫功能 促红细胞生成素 内皮素-1 |
| 收稿时间： | 2018-09-05 |
| 修稿时间： | 2019-01-24 |
Correlation between erythrocyte immune function and erythropoietin and plasma endothelin-1 in patients with angle-closure glaucoma |
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| Yun-Fang Zhang,Rui Guo,Yong-Li Liu and Gui-Ping Pan. Correlation between erythrocyte immune function and erythropoietin and plasma endothelin-1 in patients with angle-closure glaucoma[J]. International Eye Science, 2019, 19(3): 422-425 | |
| Authors: | Yun-Fang Zhang Rui Guo Yong-Li Liu Gui-Ping Pan |
| Affiliation: | Department of Ophthalmology, Taihe Hospital, Shiyan 442000, Hubei Province, China,Department of Ophthalmology, Taihe Hospital, Shiyan 442000, Hubei Province, China,Department of Ophthalmology, Taihe Hospital, Shiyan 442000, Hubei Province, China and Department of Ophthalmology, Taihe Hospital, Shiyan 442000, Hubei Province, China |
| Abstract: | AIM: To investigate the correlation between erythrocyte immune function and serum erythropoietin(EPO)and plasma endothelin-1(ET-1)in patients with angle-closure glaucoma. METHODS: Totally 30 patients with angle-closure glaucoma(case group)and 30 normal eyes(control group)were selected from our hospital from June 2017 to October 2017. The erythrocyte immune function, serum EPO and plasma ET-1 levels were measured and compared between the two groups. RESULTS: The rosette rate of erythrocyte C3b receptor in the case group was significantly lower than that in the control group(10.81%±2.01% vs 18.06%±3.44%), the rosette rate of erythrocyte immune complex was significantly higher than that in the control group(17.21%±3.49% vs 11.74%±2.14%), the serum EPO concentration was significantly higher than that in the control group(26.10%±5.22mU/mL vs 22.68%±4.06mU/mL), and the plasma ET-1 concentration was significantly higher than that in the control group(70.85%±7.16ng/L vs 58. 43±5.09ng/L). The rosette rate of erythrocyte C3b receptor in patients with angle-closure glaucoma was positively correlated with serum EPO concentration(r=0.271, P<0.05), but not with plasma ET-1 concentration. CONCLUSION: There is a positive correlation between erythrocyte immune function and serum EPO concentration in patients with angle-closure glaucoma. |
| Keywords: | angle-closure glaucoma immune function erythropoietin endothelin-1 |
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