大骨瓣开颅手术联合依达拉奉治疗重度颅脑损伤疗效分析

目的探讨大骨瓣开颅手术联合依达拉奉治疗重度颅脑损伤疗效。方法230例重度颅脑损伤患者行标准外伤大骨辩开颅减压手术，脱水、止血。随机分为治疗组（n=120）和对照组（n=110），治疗组给予依达拉奉30mg加入生理盐水100mL，静脉点滴，每日2次，连续14d；对照组除不用依达拉奉外余与治疗组相同。观察两组患者的清醒人数、觉醒时间、GCS评分的变化，并分析两组的临床疗效。结果治疗组清醒人数所占比例及治疗后GCS评分均明显高于对照组（P〈0．05）。结论大骨瓣开颅手术联合依达拉奉治疗重度颅脑损伤，能基本清除幕上颅内血肿和坏死脑组织，充分减压，提高抢救成活率，降低死亡率和致残率，值得在临床工作中加以推广。

Large Craniectomy Plus Edaravone in Treatment of Severe Craniocerebral Injury

Objective To evaluate clinical effect of large craniectomy combined with edaravone in the treatment of acute severe craniocerebral injury. Methods We divided 230 patients with acute severe craniocerebral injury randomly into the treatment group （n =120） and the control group（n= 110）. Both groups received large craniectomy for decompression and after that the treatment group was given edaravone in- jection 30mg in lO0mL normal saline, ivgtt, bid × 14d. The number of conscious patients, awakening time and GCS score in the two groups were observed and the clinical efficacy of both groups was analyzed. Results The proportion of the number of conscious patients and the GCS score after treatment in the treatment group were significantly higher than those of the control group （P〈 0.05 ） and the recovery time of consciousness was shorter in the treatment group than that in the control group（P〈0.05）. The curative rate and the total effectiveness were obviously higher in the treatment group than those in the control group（P〈 0.05 ）. Conclusion Large craniectomy combined with edaravone is worthy of wide application in the early stage of acute severe craniocerebral injury.