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Lack of association of endothelial nitric oxide synthase polymorphisms and migraine |
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| Authors: | Toriello María Oterino Agustín Pascual Julio Castillo Jesús Colás Rafael Alonso-Arranz Ana Ruiz-Alegría Carlos Quintela Estrella Montón Fernando Ruiz-Lavilla Nuria |
| Institution: | From the Services of Neurology, University Hospital "Marqués de Valdecilla," Santander, Spain (M. Toriello, A. Oterino, and A. Alonso-Arranz);Service of Neurology, University Hospital of Salamanca, Salamanca, Spain (J. Pascual);Health Center of Camargo, Cantabria, Spain (J. Castillo);Health Center of Santoña, Cantabria, Spain (R. Colás);Microbiology, University Hospital "Marqués de Valdecilla," Santander, Spain (C. Ruiz-Alegría);Health Center of Polanco, Cantabria, Spain (E. Quintela);Neurology Service of the "La Candelaria" Hospital, Tenerife, Spain (F. Montón and N. Ruiz-Lavilla). |
| Abstract: | Objective.— The aim of this study was to evaluate if 2 functional endothelial nitric oxide synthase (eNOS) gene polymorphisms might be risk factors for migraine. Background.— Nitric oxide synthase promotes the synthesis of nitric oxide (NO). NO is a potent vasodilator and mediates several processes involved in migraine pathophysiology. Only one study has suggested an association with migraine with aura. Methods.— We performed a sex- and age-matched case-control study using 2 eNOS polymorphisms (rs1800779 and rs1799983), which are in linkage disequilibrium. Genotypes were obtained with allele-specific probes in a real-time polymerase chain reaction assay. Genotypic and allelic distributions were compared with χ Results.— A total of 337 migraine patients (188 with aura) and 341 healthy controls were recruited. We found no significant differences in the distribution of genotypes and alleles for either polymorphism among clinical subgroups. Neither rs1800779 nor rs1799983 polymorphisms increased the risk for suffering from migraine aura. Conclusions.— As others have previously reported, we failed to demonstrate genetic association of the eNOS gene with migraine. |
| Keywords: | migraine migraine with aura genetic association study endothelial nitric oxide synthase gene haplotypic study |
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