| 急性脑缺血白细胞与内皮细胞粘附性变化的实验研究 |
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| 引用本文： | 周华东.急性脑缺血白细胞与内皮细胞粘附性变化的实验研究[J].生物医学工程学杂志,1999,0(4):420-422. |
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| 作者姓名： | 周华东 |
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| 作者单位： | [1]第三军医大学大坪医院 [2]重庆大学光机系 |
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| 基金项目： | 国家自然科学基金!资助项目（39670268） |
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| 摘 要： | 为探讨脑缺血再灌注损伤时局灶区白细胞的粘附变化，通过免疫荧光标记技术和显微超高速摄录像系统观察脑缺血再灌注损伤局灶区白细胞的粘附性，结果显示脑缺血再灌注损伤局灶区微动脉白细胞附壁指数升高，白细胞与内皮细胞间断裂应力降低，粘附力显著增强。上述结果表明脑缺血再灌注损伤时内皮细胞和白细胞粘附性显著增强，白细胞在脑缺血再灌注损伤中起重要作用。
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| 关 键 词： | 再灌注损伤 脑缺血 白细胞 内皮细胞 粘附力 |
An Experimental Study on the Change of Adhesion Between Leukocyte and Endothelium in Acute Cerebral Ischemia |
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| Zhou Huadong,Li Zhimin,Li Jingcheng,Chen Mane.An Experimental Study on the Change of Adhesion Between Leukocyte and Endothelium in Acute Cerebral Ischemia[J].Journal of Biomedical Engineering,1999,0(4):420-422. |
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| Authors: | Zhou Huadong Li Zhimin Li Jingcheng Chen Mane |
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| Institution: | Department of Daping Hospital, Third Military Medical University, Chongqing 400042. |
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| Abstract: | The objective of this experiment was to investigate the change of leukocyte adhesion in the focus of cerebral ischemia reperfusion injury. Immune fluorescent microscope equipped with image tube camera and high speed recording TV sets was used to study the leukocyte adhesion in the focus of cerebral ischemia reperfusion injury. The result showed that the density index of adherent leukocyte was significantly elevated, the fracture stress between leukocyte and endothelium dropped, and the adhesion increased in the focus of cerebral ischmic reperfusion injury. These findings indicated that leukocyte adhesion was increased significantly and leukocytes played an important role in the cerebral ischemia reperfusion injury. |
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| Keywords: | Ischemia reperfusion injury Cerebral ischemia Leukocyte Endothelium Adhesion |
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