Congenital diaphragmatic hernia and retinoids: searching for an etiology |
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Authors: | Sandra Montedonico Nana Nakazawa Prem Puri |
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Affiliation: | (1) The Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin 12, Ireland;(2) Centro de Investigación en Biología de la Reproducción, Escuela de Medicina, Universidad de Valparaíso, Valparaiso, Chile |
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Abstract: | Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH. |
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Keywords: | Congenital diaphragmatic hernia (CDH) Retinoids Nitrofen |
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