| 不动杆菌对碳青霉烯类抗生素的耐药机制和治疗进展 |
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| 作者姓名： | Zhang W Liu KZ |
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| 作者单位： | 浙江省肿瘤医院重症监护室,浙江,杭州,310022 |
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| 摘 要： | 不动杆菌已成为医院感染的主要致病菌.随着碳青霉烯类抗生素的广泛应用,其多重耐药菌尤其是碳青霉烯类耐药菌株的出现,给临床治疗带来了很大的难题.研究发现,不动杆菌对碳青霉烯类抗生素的耐药机制主要是灭活酶的产生,其中以染色体或质粒介导的各种碳青霉烯酶最为重要.而舒巴坦和β-内酰胺类药物合用对不动杆菌有一定的治疗协同作用.
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| 关 键 词： | 鲍氏不动杆菌/药物作用 鲍氏不动杆菌/酶学 β内酰胺酶类/遗传学 β内酰胺酶类/代谢 抗菌药/药理学 抗药性 细菌/遗传学 |
Mechanisms of carbapenems resistance in acinetobacter and progress of treatment |
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| Zhang W,Liu KZ.Mechanisms of carbapenems resistance in acinetobacter and progress of treatment[J].Journal of Zhejiang University(Medical Sciences),2010,39(5):542-547. |
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| Authors: | Zhang Wei Liu Kai-Zhong |
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| Institution: | Intensive Care Unit, Zhejiang Cancer Hospital, Hangzhou 310022, China. |
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| Abstract: | Acinetobacter has been the major pathogen of nosocomial infection. With the wide use of carbapenems, the emergence of multi-resistant isolates especially those resistant to carbapenem, brings a great problem to clinical treatment. The production of inactive enzymes is the main mechanism for antibiotic resistance, particularly the production of carbapenemases mediated by chromosome or plasmid. Combinations of β-lactam antibiotics and sulbactam may show synergism or partial synergism for acinetobacter isolates. |
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