| E-Cd在下咽癌中的表达及其临床意义 |
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| 引用本文： | 李学忠,王天铎,栾信庸,许安廷,李梅,董频.E-Cd在下咽癌中的表达及其临床意义[J].山东大学学报(医学版),1999(2). |
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| 作者姓名： | 李学忠 王天铎 栾信庸 许安廷 李梅 董频 |
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| 作者单位： | 山东医科大学附属医院耳鼻喉科 |
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| 摘 要： | 为研究Ｅ－Ｃｄ在下咽癌标本中的表达及其临床意义，应用免疫组化ＳＡＢＣ方法，研究了６５例下咽癌手术标本。结果表明，随肿瘤临床分级的升高，Ｅ－Ｃｄ表达下降；随着肿瘤分化程度的降低，Ｅ－Ｃｄ表达下降；Ｅ－Ｃｄ的表达在淋巴结转移组明显低于无淋巴结转移组（Ｐ＜０．０５）。提示Ｅ－Ｃｄ在下咽癌中具有抑制肿瘤侵袭和转移的作用，可做为下咽癌分化差和癌细胞侵袭、转移的标记物。
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| 关 键 词： | 下咽肿瘤 钙粘连蛋白 免疫组织化学 |
ECd EXPRESSION AND ITS CLINICAL SIGNIFICANCE IN HYPOPHARYNGEAL CANCER |
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| Li Xuezhong,Wang Tianduo,Luan Xinyong,et al.ECd EXPRESSION AND ITS CLINICAL SIGNIFICANCE IN HYPOPHARYNGEAL CANCER[J].Journal of Shandong University:Health Sciences,1999(2). |
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| Authors: | Li Xuezhong Wang Tianduo Luan Xinyong |
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| Abstract: | In order to study the ECd expression and its clinical significance in hypopharyngeal cancer, 65 cases of human hypopharyngeal cancer were observed by immunohistochemical technique-SABC method. The results showed that:(1) Decreased ECd expression correlated with a increased T categorization; (2) Decreased ECd expression correlated with a decreased grade of differentiation; (3) Decreased ECd expression was associated with cervical lymph node metastasis (P<0.05). The result indicates that ECd may be a suppressor molecule of invasion and metastasis; It may be used as a marker of the differentiation, invasiveness and metastases of human hypopharyngeal cancer. |
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| Keywords: | Hypopharyngeal neoplasams Cadherins Immunohistochemistry |
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