Ki-67的表达在胎盘绒毛滋养细胞生存活性评价中的作用 |
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引用本文: | 马云秀,杨国嵘,郭群,马伶,赵甲升.Ki-67的表达在胎盘绒毛滋养细胞生存活性评价中的作用[J].甘肃医药,2014,33(3):170-172. |
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作者姓名: | 马云秀 杨国嵘 郭群 马伶 赵甲升 |
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作者单位: | 马云秀 (兰州市第一人民医院病理科, 甘肃兰州,735000); 杨国嵘 (解放军第一医院病理科, 甘肃兰州,730030); 郭群 (兰州市第一人民医院病理科, 甘肃兰州,735000); 马伶 (兰州市第一人民医院病理科, 甘肃兰州,735000); 赵甲升 (兰州市第一人民医院病理科, 甘肃兰州,735000); |
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基金项目: | 兰州市医疗卫生类科技支撑计划(项目编号:2013-3-48) |
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摘 要: | 目的:探讨Ki-67的表达在胎盘绒毛滋养细胞生存活性评价中的作用.方法:应用免疫组化MaxVision法检测Ki-67在48例自然流产、48例葡萄胎和25例早期正常妊娠(作为对照组)妇女的胎盘绒毛滋养细胞中的表达情况.结果:葡萄胎组中Ki-67强阳性表达显著高于对照组和自然流产组(P<0.01).结论:在胎盘绒毛滋养细胞中,Ki-67表达降低可能导致自然流产,过表达则可导致肿瘤的发生.
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关 键 词: | Ki-67 胎盘绒毛滋养细胞 免疫组化 |
The function of Ki-67 in survival activity evaluation of placenta villi nutrient cells |
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Authors: | MA Yun-xiu YANG Guo-rong GUO Qunt MA Ling ZHAO Jia-sheng |
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Institution: | 1.Department of Pathology, the Frist People's Hospital of Lanzhou, Lanzhou 730050, China.2.Department of Pathology, the Frist Hospital of PLA, Lanzhou 730030, China) |
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Abstract: | Objective: To study The function of Ki-67 in survival activity evaluation of placenta villi nutrient cells. Methods: The expression of Ki-67 in placenta villi nutrient cells of 48 patients with early abortion and 48 patients with hydatidiform mole and 25 early normal pregnancy (as the control group)were detected by immunohistochemistry. Results: Ki - 67 strong positive expression in hydatidiform mole group is significantly higher than control group and spontaneous abortion group (P〈0.01). Conclusions:In placental villi nutrient cells, the expression of Ki-67 lower can cause spontaneous abortion, high expression can lead to the occurrence of tumor. |
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Keywords: | Ki - 67 placenta villi nutrient cell immunohistochemistry |
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