中老年男性睾酮水平与代谢综合征的相关性

目的探讨50～70岁中老年男性睾酮水平与代谢综合征（MS）的相关性。方法收集我院2005年9月至2006年9月门诊及住院50—70岁男性200例。按2005年国际糖尿病联盟关于MS的临床判断标准分成2组，MS组80例和无MS组（NMS组）120例。比较2组间睾酮水平的差异，分析2组睾酮与腰围、BMI、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）的相关性。结果2组间年龄无统计学差异（P〉0．05）。MS各成分中，除腰围及BMI2组间有明显差异，MS组明显高于NMS组，糖尿病比例、高血压比例、TG、HDL—C2组间均无明显差异。2组间睾酮水平比较，MS组睾酮水平（4.11±1．22）μg／L明显低于NMS组（5．964±1．73）μg／L（P〈0．01）。相关性分析显示，在MS组及NMS组睾酮水平均与年龄、腰围呈负相关，在NMS组睾酮水平尚与HDL—C呈正相关。结论50～70岁中老年男性更低的睾酮水平可能进一步增加MS的患病风险。

Correlation between serum androgen level and metabolic syndrome in men aged 50 to 70 years old

Objective To investigate the correlation between serum androgen level and metabolic syndrome（MS） in men aged 50 to 70 years old. Methods 200 men aged 50 to 70 years old were enrolled from September 2005 to September 2006, and were divided into two groups according to the clinical indexs of MS of international diabetes fundation（ IDF）, 80 in MS group and 120 in non metabolic syndrome （NMS） group. Serum androgen level between two groups was compared, and the correlation between serum androgen level and some components of metabolic syndrome were also investigated. Results Serum androgen level was significantly lower in MS group than that in NMS group. Relativity analysis showed that serum androgen level was significantly correlated to age and waistline;In NMS group serum androgen level was correlated to HDL-C. Conclusions Lower serum androgen level may improve the incidence of metabolic syndrome in men aged 50 to 70 years old.