凋亡抑制蛋白Bcl—2在皮肤基底细胞癌中的表达

用免疫组化方法检测了凋亡抑制基因蛋白Ｂｃｌ－２蛋白在基底细胞癌中的表达，同时分析比较了ｐ５３蛋白、Ｐａｎ－ｒａｓ蛋白和增殖细胞核抗原（ＰＣＮＡ）的表达。结果ＢＣＣ中２１／２１例Ｂｃｌ－２蛋白阳性，且几乎所有肿瘤细胞均呈阳性胞浆反应；５／１０例ｐ５３蛋白阳性，阳性细胞率小于５０％；Ｐａｎ－ｒａｓ蛋白在１０／１０例中均阴性；ＰＣＮＡ在９／１０例中阳性，但阳性细胞率小于１０％，这些表明，ＢＣＣ是一种低增

Expression of apoptosis suppressing protein Bcl 2 in cutaneous basal cell carcinoma

Bcl 2 protein was detected with immunohistochemical method in basal cell carcinoma(BCC), and compared with expression of p53 protein, Pan ras protein as well as proliferating cell nuclear antigen(PCNA). Bcl 2 expression was detected in all of 21 specimens, and Bcl 2 protein could be demonstrated in almost all tumor cell cytoplasm. p53 protein was found in 5 of 10 specimens, while the positive cells were less than 50%. Pan ras protein was not demonstrated in all 10 specimens examined. PCNA expression was detected in 9 of 10 cases, but the PCNA positive cells were no more than 10%. These findings suggest that the over expression of Bcl 2 protein and apoptosis suppresing action may play a role in the tumorigenesis and clinical biological behavior of BCC.