超敏C-反应蛋白在急性冠状动脉综合征患者外周血水平的变化及其临床价值

目的观察超敏C-反应蛋白(hs-CRP)在急性冠状动脉综合征(ACS)患者外周血的变化,探讨其在急性冠状动脉综合征中的临床应用价值。方法应用免疫透射比浊法测定急性心肌梗死患者(n=30)、不稳定型心绞痛患者(n=30)、稳定型心绞痛患者(n=30)、健康志愿者(n=30)的外周血hs-CRP水平。结果急性心肌梗死、不稳定型心绞痛、稳定型心绞痛与健康志愿者各组外周血hs-CRP水平分别为(13.17±6.60)m IU/L、(8.98±5.16)m IU/L、(3.03±1.60)m IU/L、(2.06±1.63)m IU/L。急性心肌梗死、不稳定型心绞痛患者hs-CRP水平显著高于稳定型心绞痛、健康志愿者(P<0.05),急性心肌梗死与不稳定型心绞痛比较亦差异无统计学意义(P>0.05);稳定型心绞痛与健康志愿者hs-CRP水平差异无统计学意义(P>0.05)。在ACS患者中,冠状动脉三支病变组患者外周血hs-CRP水平显著高于双支病变和单支病变组患者(P<0.05)。结论hs-CRP在ACS患者外周血水平明显升高,提示hs-CRP对心肌缺血损害、鉴别不稳定型心绞痛有参考价值。

The change and its significance of circulating high sensitive C-reactive protein in patients with acute coronary syndrome

Objective To study the change and its significance of circulating high sensitive C-reactive protein in patients with acute coronary syndrome.Methods The serum levels of hs-CRP were detected in 31 acute myocardial infarction(AMI),30 unstable angina(UA),30 stable angina(SA) patients and 30 healthy cases.Results The hs-CRP levels of AMI group ((13.17±6.60))mIU/L]and UA group(8.98±5.16)mIU/L] were significantly higher than those of SA group (3.03(±1.60))mIU/L] and healthy group (2.06±(1.63))mIU/L](P<0.05),and the hs-CRP level in AMI group was much higher than that of UA group(P<0.05),and the hs-CRP levels between SA group and healthy group had no significant difference.In patients with ACS,tie hs-CRP level of three branch vessel disease subgroup was higher than those of two branch vessel disease and single vessel disease subgroup(P<0.05).Conclusions The increase of hs-CRP level has some value in the diagnosis of ACS and the differentiation of UA.