| 甲型肝炎早期血清学诊断的探讨 |
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| 引用本文： | 任培上,张铮,李沛涛.甲型肝炎早期血清学诊断的探讨[J].中南大学学报(医学版),1984(2). |
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| 作者姓名： | 任培上 张铮 李沛涛 |
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| 作者单位： | 湖南医学院第一附属医院传染病科
(任培上，张铮)，湖南医学院微生物学教研组(李沛涛) |
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| 摘 要： | 26例甲型肝炎患者血清以二巯基乙醇处理,比较处理前后的补体结合反应滴度,以检测甲型肝炎IgM抗体。处理后滴度下降4倍或4倍以上者14例,阳性率为53％。9例双(三)份血清中有2例甲型肝炎IgM抗体可持续存在一年左右。对上述14例血清作酶联免疫吸附测定,结果不论急性期或恢复期血清甲型肝炎IgM和IgG抗体均为阳性,未能达到鉴别早期病人的目的。本文对其原因作了讨论。
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| 关 键 词： | 甲型病毒肝炎 早期血清学诊断 |
EXPLORATION FOR EARLY SERODIAGNOSIS OF VIRAL HEPATITIS A |
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| Ren Peishang Zhang ZhengDeportment of Infections Diseases,The First Affiliated Hospital,Hunan Medical collegeLi Peitao.EXPLORATION FOR EARLY SERODIAGNOSIS OF VIRAL HEPATITIS A[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1984(2). |
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| Authors: | Ren Peishang Zhang ZhengDeportment of Infections Diseases The First Affiliated Hospital Hunan Medical collegeLi Peitao |
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| Institution: | Ren Peishang Zhang ZhengDeportment of Infections Diseases,The First Affiliated Hospital,Hunan Medical collegeLi PeitaoDepartment of Microbiology,Hunan Medical College |
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| Abstract: | Complement fixation liters of the sera of 26 cases of viral hepatitis type A were compared before and after being treated with 2-mercapto-ethanol (2-ME) for the detection of HAV IgM antibody. 14 cases (53%) were positive and showed a 4-fold or more decrease in titer after such a treatment. Among them 9 cases were examined with paired sera, 2 cases persistently showed positive ami-HAV IgM over one year. The sera of these 14 cases were also tested by ELISA with a reagent box prepared by the Jejiang Institute of Health.Both ami-HAV IgM and ami-HAV IgG were demonstrated either in the sera of acute phase or convalescent phase. Thus, the goal of early serodiagnosis can not be reached by using this preparation. |
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| Keywords: | Hepatitis A Early serodiagnosis |
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