IgG4 autoantibodies to DNA in systemic lupus erythematosus patients |
| |
| Authors: | S Nagpal M S Namboodiri B S Rao P V Rao |
| |
| Affiliation: | Department of Biochemistry, Indian Institute of Science, Bangalore. |
| |
| Abstract: | The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay. A patient with distal interphalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass. These autoantibodies directed against the dsDNA conformation cross-reacted with chondroitin sulfate, dermatan sulfate and heparin. |
| |
| Keywords: | |
|
|
