Tracheal Stenting has Minimal Impact on Survival in Anaplastic Thyroid Carcinoma |
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Authors: | Parameswaran Rajeev Tarek Ezzat Mark Slade Gregory Paul Sadler Radu Mihai |
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Affiliation: | 1. Department of Endocrine Surgery, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK 2. Department of Respiratory Medicine, Oxford Radcliffe Trust, Oxford, UK
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Abstract: | Background Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer and it has an extremely poor prognosis. Rapid airway compromise is the main cause of death in patients with ATC. Methods The present study is based on a retrospective review of clinical data of patients with ATC treated over the last decade in a tertiary referral center. Results Between January 1998 and December 2010, 31 patients (13 males: 18 females) with a mean age of 74 years (range: 54–90 years) had a diagnosis of ATC made on fine-needle aspiration (n = 29) or biopsy (n = 2). Eight patients underwent total thyroidectomy and lymph node dissection, and five patients had attempted surgery but the procedure was abandoned because of inoperability. Airway compromise was clinically apparent in 11 patients. Five patients had tracheal stents inserted, with a median survival of 2 months (range: 1–36 months). In the whole cohort, 29 patients died of the disease, with a mean survival of 7 months (range: 1–36 months). Conclusions Survival of patients with undifferentiated thyroid cancer is severely compromised by airway obstruction. Palliation with tracheal stenting can rescue catastrophic airway obstruction but offers minimal survival benefit. |
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