Unaffected blood boron levels in newborn infants treated with a boric acid ointment |
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| Authors: | B. Friis-Hansen B. Aggerbeck J. Aas Jansen |
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| Affiliation: | Department of Neonatology, University Hospital (Rigshospitalet), Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark;Medical Department, A/S Alfred Benzon, Halmtorvet 29, DK-1700 Copenhagen V, Denmark;Department of Pharmacology, University of Copenhagen, Juliane Mariesvej 20, DK-2100 Copenhagen Ø, Denmark |
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| Abstract: | No rise in the boron content of the plasma of 22 newborn infants was demonstrated following repeated daily application of a water-emulsifying ointment containing the equivalent of 3% boric acid to the napkin region. The mean plasma-boron concentration fell over 5 days from a pretreatment value of 0·49 to 0·29 mg/litre, the corresponding values in ten untreated neonates being 0·62 and 0·21 mg/litre, respectively. No statistically significant differences were found. The results confirm the safety of such ointments for application to the skin, a conclusion predicted by theoretical estimates of the maximum possible boric acid absorption following application of the ointment. |
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| Keywords: | To whom reprint requests should be addressed. |
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