中医对肝豆状核变性病因病机及辨证论治的探索

以中医理论为指导,根据肝豆状核变性的临床表现、病因病理及演变规律,对肝豆状核变性中医病因病机及辨证论治进行探讨,提出其病因病机为禀赋不足、铜毒内生,铜浊邪毒、酿生湿热,火热燔灼、引动肝风,痰瘀互结、形成癥积。临床治疗当谨守病机,辨证论治,如湿热内蕴型治以清热化湿、通腑利尿,用大黄、黄连、半枝莲等组成的肝豆汤治疗;痰瘀互结型治以祛痰化瘀、活血散结,用郁金、姜黄、莪术、丹参等组成的肝豆灵片治疗。

TCM etiology, pathogenesis and syndrome differentiation and treatment of epatolenticular degeneration

The TCM etiology,pathogenesis and syndrome differentiation and treatment of epatolenticular degeneration were discussed according to the clinical symptoms,causes,pathology and development laws of the disease and TCM theory.The authors indicated that its etiology and pathogenesis included innate deficiency,internal copper toxin,accumulated dampness-heat,liver wind primed by heat-fire,and aggregation-accumulation due to binding of phlegm and blood stasis.The type of accumulated dampness-heat is treated,based on the therapy of clearing heat and resolving dampness and relaxing bowels and increasing urine excretion,with Gandou Tang consisting of Dahuang(Radix et Rhizoma Rhei),Huanglian(Rhizoma Coptidis) and Banzhilian(Hrba Scutellariae Barbatae),etc.The type of binding of phlegm and blood stasis is treated,based on the therapy of dispelling phlegm and resolving blood stasis,activating blood and dissipating binds with Gandouling Pian consisting of Yujin(Radix Curcumae),Jianghuang(Rhizoma Curcumae Longae),Ezhu(Rhizoma Zedoariae) and Danshen(Radix Salviae Miltiorrhizae),etc.