| 肺表面活性物质不同应用方式对家兔急性肺损伤气体交换的影响 |
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| 引用本文： | 张蕴,付研.肺表面活性物质不同应用方式对家兔急性肺损伤气体交换的影响[J].中国医药导刊,2006,8(4):289-291. |
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| 作者姓名： | 张蕴 付研 |
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| 作者单位： | 首都医科大学附属北京同仁医院急诊科,北京,100730 |
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| 摘 要： | 目的:探讨肺表面活性物质(pulmonary surfactant,PS)不同应用方式对家兔急性肺损伤气体交换的影响。方法:18只健康新西兰大白兔经盐水反复灌洗后致PaO2／FiO2<200mmHg,随机分为3组,每组6只,PS(100mg／kg)采用注入法(T1组)和肺灌洗法(T2组),对照组(T3组)采用同等量生理盐水滴入。观察治疗后PaO2／FiO2、PaCO2和气道吸气峰压(PIP)的变化。结果:T1、T2组治疗后各时间段PaO2／FiO2均较治疗前明显改善,T2组较T1更为显著(P<0．05);T2组气道峰压(PIP)较治疗前明显下降,并与其它各组相比差异有显著性(P<0．05)。结论:ARDS早期采用外源性PS替代治疗可以明显改善肺氧合,肺灌注方法较注入法更优。
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| 关 键 词： | 肺表面活性物质 肺灌洗 急性肺损伤 兔 |
| 文章编号： | 1009-0959(2006)04-0289-03 |
Efficacy of Different Administrations of Pulmonary Surfactant on Pulmonary Gas Exchange after Acute Lung Injury in Rabbits |
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| Zhang Yun,Fu Yan.Efficacy of Different Administrations of Pulmonary Surfactant on Pulmonary Gas Exchange after Acute Lung Injury in Rabbits[J].Chinese Journal of Medicinal Guide,2006,8(4):289-291. |
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| Authors: | Zhang Yun Fu Yan |
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| Institution: | Department of Emergency,Beijing Tongren Hospital of Capital University of Medical Science, Beijing 100730, China |
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| Abstract: | Objective: To investigate the effect of different administrations of pulmonary surfactant on pulmonary gas exchange after acute lung injury in rabbits. Methods:The rabbits with PaO2/FiO2 less than 200mmHg after lung lavage by normal saline were randomly divided into three groups, with 6 in each group. The pulmonary surfactant( 100mg/kg)was given by instillation(T1 group)and by pulmonary lavage(T2 group).The same volume of saline was used to substitute the pulmonary surfactant in T3 group.Results: PaO2/FiO2 dramatically improved in group T1 and T2(P < 0.05) . The PIP decreased markedly(P < 0.05)soon after the lungs were lavaged by pulmonary surfactant in group T2. Conclusion: Lavage administration of pulmonary surfactant seems to be a promising method in the treatment of acute lung injury. |
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| Keywords: | pulmonary surfactant lung lavage acute lung injury rabbit |
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