EFFECTS OF PIPECURONIUM AND PANCURONIUM ON THE ISOLATED RABBIT HEART |
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| Authors: | DEAM, R. K. SONI, N. |
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| Affiliation: | 1Anaesthetic Department, Royal Free Hospital Pond Street, Hampstead, London
2Magil Department of Anaesthetics, Westminster Hospital Page Street, London |
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| Abstract: | We have studied the effects of pipecuronium and pancuroniumon myocardial contractility and heart rate in two differentanimal preparations. Pipecuronium and pancuronium produced nochange in isometric contraction of rabbit atria. The chronotropiceffects of pipecuronium, pancuronium and vecuronium were investigatedusing acetylcholine as an agonist in isolated perfused rabbitheart. Pancuronium but not pipecuronium or vecuronium, produceda significant degree of antagonism to the bradycardia producedby acetylcholine. |
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