| 乳腺癌MCF-7/Adr耐药细胞CD95分子的多态性表达和功能缺陷 |
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| 引用本文： | 陈俊,张积仁,周殿元. 乳腺癌MCF-7/Adr耐药细胞CD95分子的多态性表达和功能缺陷[J]. 癌症, 2000, 19(4): 307-310 |
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| 作者姓名： | 陈俊 张积仁 周殿元 |
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| 作者单位： | [1]第一军医大学珠江医院肿瘤中心 [2]第一军医大学南方医院消化科 |
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| 摘 要： | 目的：观察ＭＣＦ－１／Ａｄｔ耐药细胞ＣＤ９５分子的表达和功能及其与药敏细胞的差异，初步探讨ＣＤ９５缺陷与多药耐药的潜在关系。方法：对乳腺癌ＭＣＦ－７／Ａｄｔ耐药细胞的ＭＣＦ－７药物敏感细胞进行对比研究。流式细胞仪检测ＣＤ９５蛋白水平，ＲＴ－ＰＣＲ分析ＣＤ９５ ｍＲＮＡ转录体的多态性。碘化内啶染色和ＤＮＡ琼脂糖凝胶电泳观测抗ＣＤ９５单克隆抗体对ＭＣＦ－７／Ａｄｔ耐药细胞的诱导凋亡效应。结果：ＭＣＦ－
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| 关 键 词： | MCF－7／Adr CD95 分子多态性 乳腺癌 |
| 修稿时间： | : |
The deficiency of CD95(APO-1/Fas)in expression and function on drug resistant cell line MCF-7/Adr |
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| CHEN Jun ,ZHANG Ji ren ,ZHOU Dian yuan Center of Oncology,Zhujiang Hospital,First Military Medical University,Guangzhou,,P R China Nanfang Hospital,First Military Medical University,Guangzhou,,P R China. The deficiency of CD95(APO-1/Fas)in expression and function on drug resistant cell line MCF-7/Adr[J]. Chinese journal of cancer, 2000, 19(4): 307-310 |
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| Authors: | CHEN Jun ZHANG Ji ren ZHOU Dian yuan Center of Oncology Zhujiang Hospital First Military Medical University Guangzhou P R China Nanfang Hospital First Military Medical University Guangzhou P R China |
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| Affiliation: | CHEN Jun 1,ZHANG Ji ren 1,ZHOU Dian yuan 2 1 Center of Oncology,Zhujiang Hospital,First Military Medical University,Guangzhou,510280,P R China 2 Nanfang Hospital,First Military Medical University,Guangzhou,510280,P R China |
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| Abstract: | |
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| Keywords: | CD95 Multidrug resistance MCF 7/Adr |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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