| 早期原发性高血压患者血管内皮功能研究 |
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| 引用本文： | 徐宛玲,张梅花,张玲,张莹. 早期原发性高血压患者血管内皮功能研究[J]. 现代预防医学, 2011, 38(4): 781-782,784 |
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| 作者姓名： | 徐宛玲 张梅花 张玲 张莹 |
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| 作者单位： | 漯河医学高等专科学校第三附属医院内科,漯河,462002 |
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| 摘 要： | [目的]观察早期原发性高血压患者肱动脉内皮功能状态和血管活性物质的变化。[方法]对40例早期原发性高血压患者(早期高血压组)和40例健康对照者(对照组),以高分辨率超声测定肱动脉血流介导内皮依赖性舒张功能(FMD),并检测血一氧化氮(NO)、降钙素基因相关肽(CGRP)、血浆内皮素(ET-1)、假性血管性血友病因子(VWF)的变化。[结果]早期原发性高血压组的FMD和NO、CGRP降低,ET-1、VWF升高,与健康对照组相比差异有统计学意义(P﹤0.05)。血NO水平变化与FMD的变化一致(r=0.511,P﹤0.01)。[结论]原发性高血压患者在早期已发生肱动脉内皮依赖性舒张功能降低,与NO水平下降有关。
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| 关 键 词： | 原发性高血压 肱动脉 内皮依赖性舒张功能 一氧化氮 |
RESEARCH ON VASCULAR ENDOTHELIAL FUNCTION IN PATIENTS WITH EARLY-STAGE PRIMARY HYPERTENSION |
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| XU Wan-ling,ZHANG Mei-hua,ZHANG Ling,et al.. RESEARCH ON VASCULAR ENDOTHELIAL FUNCTION IN PATIENTS WITH EARLY-STAGE PRIMARY HYPERTENSION[J]. Modern Preventive Medicine, 2011, 38(4): 781-782,784 |
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| Authors: | XU Wan-ling ZHANG Mei-hua ZHANG Ling et al. |
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| Affiliation: | XU Wan-ling,ZHANG Mei-hua,ZHANG Ling,et al.(Department of Cardiology,The Third Affiliated Hospital of Luohe Medical College,Luohe 462002,China) |
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| Abstract: | [Objective] To observe the status of brachial artery endothelial function and changes of vasoactive substances in patients with early-stage primary hypertension.[Methods] 40 patients with early-stage primary hypertension and 40 healthy normal control subjects were selected.Endothelium-dependent flow-mediated dilation(FMD) was assessed on the brachial artery using high-resolution ultrasound.The plasma levels of nitric oxide(NO),Calcitonin gene related peptide(CGRP),endothelial-I(ET-I) and Von Willebrand fact... |
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| Keywords: | Primary hypertension Brachial artery Endothelium-dependent diastole function Nitric oxide |
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