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| 正交试验优化盐酸特拉唑嗪渗透泵控释片生产工艺 | |
| 引用本文： | 马廷升,李高,宋思才,刘志华,朱兰寸. 正交试验优化盐酸特拉唑嗪渗透泵控释片生产工艺[J]. 中南药学, 2011, 9(4): 252-254. DOI: 10.3969/j.issn.1672-2981.2011.04.004 |
| 作者姓名： | 马廷升 李高 宋思才 刘志华 朱兰寸 |
| 作者单位： | 1. 怀化医学高等专科学校药学系,湖南,怀化,418000 2. 华中科技大学同济医学院药学院,武汉,430030 3. 怀化正好制药有限公司,湖南,怀化,418000 |
| 基金项目： | 湖南省教育厅自然科学基金资助项目 |
| 摘 要： | 目的研究盐酸特拉唑嗪渗透泵控释片生产的最佳工艺。方法采用正交实验设计L9(34),以药物25 h累积释药百分率为评价指标筛选工艺。结果优选实验因素:促渗剂用量为(w/w)20%、促渗透聚合物CMC-Na用量(w/w)为6%、包衣液增重(w/w)为4%、释药孔径为600μm。渗透泵控释片25 h累积释药百分率平均值为82.6%,RSD为2.65%(n=5)。结论由正交试验筛选制备盐酸特拉唑嗪渗透泵控释片的工艺条件是可靠的,为该药的靶向制剂、缓控制剂的药剂学研究奠定基础。 |
| 关 键 词： | 盐酸特拉唑嗪 控释片 渗透泵 生产工艺 正交试验 |
Preparation of oral osmotic pump tablets of terazosin hydrochloride |
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| MA Ting-sheng,LI Gao,SONG Si-cai,LIU Zhi-hua,ZHU Lan-cun. Preparation of oral osmotic pump tablets of terazosin hydrochloride[J]. Central South Pharmacy, 2011, 9(4): 252-254. DOI: 10.3969/j.issn.1672-2981.2011.04.004 | |
| Authors: | MA Ting-sheng LI Gao SONG Si-cai LIU Zhi-hua ZHU Lan-cun |
| Affiliation: | MA Ting-sheng1,LI Gao2,SONG Si-cai3,LIU Zhi-hua1,ZHU Lan-cun1 (1.Department of Pharmacology,Huaihua Medical College,Huaihua Hunan 418000,2.Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,3.Zhenghao Pharmaceutical Corporation,Huaihua Hunan 418000) |
| Abstract: | Objective To determine the best preparation craft of oral osmotic pump tablets of terazosin hydrochloride.Methods Taking the 25 h cumulative drug delivering percentage as the index,the oral osmotic pump tablets of terazosin hydrochloride were prepared by ultrasonic dispersing method with orthogonal design L9(34).Results Optimal experiment factors were as follows: the dosage of penetration enhancers agent was 20%(w/w),the dosage of penetration enhancers polymer CMC-Na was 6%(w/w),the weight increment of coat... |
| Keywords: | terazosin hydrochloride controlled delivery preparation craft orthogonal test |
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