| 尼群地平对氯氮平血药浓度及疗效的影响 |
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| 引用本文： | 张跃坤,赵丽琼,瞿天一.尼群地平对氯氮平血药浓度及疗效的影响[J].现代预防医学,2011,38(4):775-776. |
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| 作者姓名： | 张跃坤 赵丽琼 瞿天一 |
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| 作者单位： | 云南省精神病医院,昆明,650224 |
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| 摘 要： | 目的]探讨尼群地平对氯氮平血药浓度及疗效的影响。方法]将长期住院精神分裂症伴高血压,且一直单一服用氯氮平治疗的70例患者,随机分为两组,对照组35例延用氯氮平治疗(200～500mg/d),研究组35例在延用氯氮平(剂量不变)的同时,合用尼群地平(20～30mg/d)治疗,治疗12周,以阳性症状与阴性症状量表(PANSS)评定疗效,用高效液相色普法(HPLC)测定氯氮平稳态血药浓度。结果]合用尼群地平治疗组(研究组),在第8周末、12周末,氯氮平血药浓度升高,差异有统计学意义(P﹤0.05),12周末PANSS总分、阳性症状评分和阴性症状评分均有下降,差异有统计学意义(P﹤0.05)。结论]尼群地平合用氯氮平治疗精神分裂症伴高血压患者时,会影响到氯氮平的血药浓度升高,但不影响其疗效。
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| 关 键 词： | 尼群地平 氯氮平 血药浓度 疗效 |
INFLUENCE OF NITRENDIPINE ON PLASMA CONCENTRATION AND THERAPEUTIC EFFECT OF CLOZAPINE |
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| ZHANG Yue-kun,ZHAO Li-qiong,QU Tian-yi.INFLUENCE OF NITRENDIPINE ON PLASMA CONCENTRATION AND THERAPEUTIC EFFECT OF CLOZAPINE[J].Modern Preventive Medicine,2011,38(4):775-776. |
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| Authors: | ZHANG Yue-kun ZHAO Li-qiong QU Tian-yi |
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| Institution: | ZHANG Yue-kun,ZHAO Li-qiong,QU Tian-yi.(Psychiatric Hospitals in Yunnan Province,Kunming 650224,China) |
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| Abstract: | Objective] To explore the influence of nitrendipine on plasma concentration and therapeutic effect of clozapine.Methods] The 70 schizophrenia patients with high blood pressure,who had a single treatment of clozapine in a long time,were randomly divided into two groups.35 patients were treated with clozapine(200-500 mg/day) and the other 35 patients were treated with clozapine(200-500 mg/day) combined with nitrendipine(20-30 mg/day).Both groups were treated for 12 weeks.The positive symptoms and negative s... |
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| Keywords: | Nitrendipine Clozapine Plasma concentration Therapeutic effect |
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