Chronic Istaroxime Improves Cardiac Function and Heart Rate Variability in Cardiomyopathic Hamsters |
| |
| Authors: | Pietro Lo Giudice Giovan Giuseppe Mattera Jean-Pierre Gagnol Franco Borsini |
| |
| Affiliation: | (1) Research and Development, Pharmacology Department, Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Via Pontina km 30.400, 00040 Pomezia, Rome, Italy;(2) University of Montpellier 1 and CNRS UMR5232, Montpellier, France |
| |
| Abstract: | Purpose Istaroxime is a new luso-inotropic compound. It exerts inotropic action by reducing Na+/K+-ATPase activity, and simultaneously it stimulates sarcoplasmic reticulum Ca2+-ATPase function, thus also inducing lusitropic action. The aim of present study is to assess the effect of chronic istaroxime treatment on cardiac function and heart rate variability in Bio TO.2 Syrian hamster model of progressive heart failure. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
