左旋门冬酰胺酶治疗急性淋巴细胞白血病期间凝血功能异常处理的意义

目的探讨急性淋巴细胞性白血病采用左旋门冬酰胺酶(L-Asp)治疗期间凝血功能异常有无必要输冷沉淀。方法对62例患者进行152次L-Asp治疗,将用药后凝血功能异常的患者活性的部分凝血活酶时间(APTT)在45～240 s]分为对照组和干预组(输4～6 U冷沉淀),分析应用L-Asp治疗前后凝血功能指标,即凝血酶原时间(PT)、APTT、凝血酶时间(TT)、纤维蛋白原定量(FIB)。结果干预组给予4～6 U冷沉淀,次日复查凝血功能,93%的人正常,7%的人7 d后正常;对照组不干预观察7 d多数人正常,两组均无出血倾向。结论对L-Asp治疗后APTT在45～240 s的凝血功能异常患者暂无必要输冷沉淀。

The significance of the treatment of coagulation abnormal during L-asparaginase (L-asp) therapy on patients with acute lymphoblastic (ALL)

Objective To explore whether it is necessary to inject cryoprecipitate during L-asparaginase(L-asp) treatment on patients whose coagulation is abnormal with acute lymphoblastic(ALL). Methods 62 patients were treated 152 times by L.Asp and then divided the patients whose APTT was from 45~240s into control groups and treated group(inject cryoprecipitate 4~6U).Prothrombin time(PT),APTT,thrombin time(TT) and fibrinogen(FIB) were analyzed before and during treatment with L-Asp. Results Treated group were injected cryoprecipitate 4~6U and checked the coagulation function.Coagulation function of 93% people were normal and coagulation function of other 7% people were normal after 7 days.Control group were no treatment and coagulation function is normal after 7 days.There were no patients of bleeding in the two groups. Conclusion There is no necessary to inject cryoprecipitate to patients whose coagulation function is abnormal and APTT is from 45~240s.