Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil |
| |
| Authors: | Kensuke Shiraishi Yoshimasa Takeda Kenichi Masui Hideki Taninishi Toshihiro Sasaki Tetsuya Danura Kiyoshi Morita |
| |
| Affiliation: | (1) Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama Okayama, 700-8558, Japan;(2) Department of Anesthesiology, National Defense Medical College, Tokorozawa, Japan |
| |
| Abstract: | Purpose Temporary brain ischemia occurring during surgery under general anesthesia may induce the death of neuronal cells and cause severe neurological deficits. On the other hand, it is not clear whether μ-opioid receptor agonists promote ischemic brain injury. It is known that duration of ischemic depolarization affects the degree of neuronal damage. However, the effects of fentanyl during brain ischemia on ischemic depolarization have not been investigated. Therefore, in the current study, the effects of fentanyl on ischemic neuronal damage and ischemic depolarization were quantitatively evaluated. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
