二维斑点追踪技术评价冠心病患者心肌功能的研究

目的：应用二维斑点追踪成像（ speckle tracking imaging, STI）技术对常规方法显示室壁运动正常的冠心病患者进行定量分析,探讨STI技术用于诊断冠心病的临床应用价值。方法采集经冠状动脉造影证实的50例冠心病和40例对照组患者的心尖长轴、四腔和两腔观的二维灰阶动态图像,测量比较两组各节段纵向收缩期峰值应变（ global longitudinal systolic peak strain, GLPS）及整体纵向平均应变（ GLPS?Avg）,应用受试者工作特征曲线（ receiver operating characteristic curve, ROC曲线）评价GLPS?Avg对筛选冠心病的敏感性和特异性。结果冠心病组各节段心肌的GLPS均明显低于对照组,差异性具统计学意义（P＜0?05）。 GLPS?Avg 冠心病组（－15?79％±3?35％）绝对值低于正常组（－19?02％±2?78％）的绝对值,有统计学差异（P＜0?05）。 ROC曲线显示以GLPS?Avg－17?7％作为筛选冠心病的截断值,其诊断敏感性为77?5％,特异性为60?0％,AUC＝0?777。结论 STI作为早期诊断冠心病的指标是可行的。

Evaluation of myocardial function in patients with coronary heart disease by speckle tracking imaging

Objective To investigate the clinical value of speckle tracking imaging ( STI ) in the diagnosis of coronary heart disease ( CHD ) with normal ventricular wall motion? Methods According to the results of coronary angiography, 50 patients with CHD and 40 age?matched subjects were enrolled? The two?dimensional loop?cines were obtained in apical 4-chamber view, apical 2-chamber view and long axis view of left ventricle? Globe longitudinal systolic peak strain ( GLPS ) and average globe longitudinal systolic peak strain ( GLPS?Avg) were measured and calculated? GLPS?Avg were applied to evaluate the diagnostic efficiency for CHD by receiver operating characteristic curve? Results The absolute value of GLPS_Avg in CHD group (-15?79%± 3?35%) was significantly decreased compared with that of the normal group (-19?02%± 2?78%)?The cutoff value of GLPS?Avg to diagnose CHD was-17?7%, with the sensitivity 77?5% and specificity 60?0%.Conclusions GLPS?Avg with STI technique was helpful to diagnose CHD.