病毒性肝炎患者心理健康状况及激素水平的相关研究

目的：探讨病毒性肝炎（Viral Hepatitis,VH)患者的心理状态、内分泌变化及与肝功能的关系。方法：VH患者的结果与常模比较，心理测验同时检测血浆皮质醇（Cortisol,CT)、血管紧张素Ⅱ（An-giotensinⅡ,ATⅡ)及主要肝功指标，其结果与对照组比较。结果：测定VH患者SAS、SDS得分、慢性肝炎（CH）组ScL-90“躯体化、抑郁、焦虑、精神病性”及EPQ的“P、N”维度得分均明显高于常模且差异有显著性（P＜0．05或0．001）。VH病人急性期血浆ATⅡ、CT含量增高并与黄疸程度平行（P＜0．05或0．01）。ATⅡ发展与多项心理、肝功能指标有相关性（P＜0．05－0．001）。结论：CH病人的心理健康水平低于并具精神质及情绪不稳定的个性特征，是应予心理学手段干预的特殊群体。VH病人血浆CT和ATⅡ含量增高并与肝功能相关。ATⅡ水平与心理测验得分正相关，是有价值的心理应激激素指标之一。

Levels of Cortisol and Angiotensin-II in Patients with Viral Hepatitis and their Psychological Status

Objective:To investigate mental and physical aspects of patients with viral hepatitis Methods:198 patients with viral hepatitis in our hospital were sampled continuously Their cortisol levels and AT-II (angiotensin-II) levels were measured SAS, SDS, SCL-90 and EPQ were instruments to get the psychological data Results: The scores of SAS and SDS of patients were significantly higher than Chinese norm Chronic patients had higher subscores in SCL-90 than norm, and higher N and P scores in EPQ There was parallel relatonship between levels of AT-II\cortisol and severity of jaundice in acute patients The plasma level of AT-II was associated with most of the psychological index and abnormality of liver function Conclusion:Patients with viral hepatitis have both psychological and physical disturbances Ag-II is a useful index to these disturbances