玉米蛋白及其水解产物对自发性高血压大鼠降血压作用的研究

目的探讨玉米蛋白及其水解产物对自发性高血压大鼠(SHR)血压的影响。方法 6～8周龄雄性SHR大鼠60只随机分为A组(玉米蛋白组)、B组(胃蛋白酶水解产物组)、C组(胰蛋白酶水解产物组)、D组(复合酶水解产物组)和E组(生理盐水对照组),每组12只动物,均以1 g/kg体重剂量灌胃,测定灌胃0、1、2、4、6、8h后SHR血压值。结果胃蛋白酶水解产物、胰蛋白酶水解产物和复合酶水解产物在0～6 h内对SHR的血压升高具有明显抑制作用,其中0～2 h内降血压效果明显;各组水解产物中,以复合酶水解产物在0～6 h内降压效果最佳,SBP与生理盐水对照组、胃蛋白酶水解产物组和胰蛋白酶水解产物组相比具有极显著差异(P<0.01)。结论玉米蛋白胃蛋白酶、胰蛋白酶和复合酶水解产物能有效地降低SHR大鼠的血压,为其在保健食品领域及医药方面的开发应用提供了参考。

Antihypertensive Effects of Corn Protein and its Hydrolysates on Blood Pressure in Spontaneously Hypertensive Rats

Objective To study the antihypertensive effects of s corn protein and its hydrolysates on spontaneously hypertensive rats(SHR).Methods Sixty 6~8 week-old male SHR were randomly divided into 5 groups: group A(corn protein),group B(corn protein’s hydrolysate prepared with pepsin),group C(corn protein’s hydrolysate prepared with trypsin),group D(corn protein’s hydrolysate prepared with complex enzyme) and group E(saline).Each group were orally adiministered at dose of 1g/kg body weight.Subsequently,systolic blood pressure of SHR was measured at a fixed time interval(0,1,2,4,6 and 8 h) post-adiministration.Results Results showed that all hydrolysates had significant inhibition on blood pressure of SHR and compound enzyme hydrolysate had the strongest effect on antihypertension during 0~6 h,with SBP decreased significantly which compared with group A,B,C and E(P<0.01).Conclusion A significant decrease in systolic blood pressure of SHR was observed in group,B,C and D.