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| D-氨基葡萄糖盐酸盐体外抗肿瘤及其免疫调节作用 | |
| 引用本文： | 曹秀明,张珍珠,刘万顺. D-氨基葡萄糖盐酸盐体外抗肿瘤及其免疫调节作用[J]. 中国生化药物杂志, 2008, 29(1): 51-53 |
| 作者姓名： | 曹秀明 张珍珠 刘万顺 |
| 作者单位： | 1. 哈尔滨商业大学药物研究所,黑龙江哈尔滨,150076;中国海洋大学生命学院,山东青岛266003 2. 哈尔滨商业大学药物研究所,黑龙江哈尔滨,150076 3. 中国海洋大学生命学院,山东青岛,266003 |
| 基金项目： | 黑龙江省杰出青年科学基金 |
| 摘 要： | 目的研究D-氨基葡萄糖盐酸盐(GAH)体外抗肿瘤作用和免疫增强作用。方法MTT法观察体外GAH对肿瘤细胞生长和小鼠淋巴细胞增殖的影响,酶联免疫法(ELISA)观察GAH对淋巴细胞分泌细胞因子IL-2的影响。结果GAH明显抑制SGC-7901细胞的生长,对HepG-2、LS-174细胞生长的抑制作用较弱。GAH具有有丝分裂原样的作用,能够诱导淋巴细胞增殖并且分泌IL-2。结论GAH有一定的抗肿瘤作用和免疫增强作用。 |
| 关 键 词： | D-氨基葡萄糖盐酸盐 抗肿瘤 淋巴细胞增殖 IL-2 |
| 文章编号： | 1005-1678（2008）01-0051-03 |
| 收稿时间： | 2007-07-09 |
| 修稿时间： | 2007-07-09 |
The effects of D-Glucosamine Hydrochloride on antitumor and immune regulation in vitro |
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| CAO Xiu-ming,ZHANG Zhen-zhu,LIU Wan-shun. The effects of D-Glucosamine Hydrochloride on antitumor and immune regulation in vitro[J]. Chinese Journal of Biochemical Pharmaceutics, 2008, 29(1): 51-53 | |
| Authors: | CAO Xiu-ming ZHANG Zhen-zhu LIU Wan-shun |
| Abstract: | Purpose To study the effects of D-Glucosamine Hydrochloride(GAH)on antitumor and immune regulation in vitro.Methods The effects of GAH on antitumor and lymphocytes proliferation were observed by MTT,and IL-2 were observed by ELISA.Results GAH could inhibited the growth of SGC-7901.GAH could induce lymphocytes proliferation and significantly increase the secretion of IL-2 in treatment group.Conclusion GAH had effects on anti-tumour and immune regulation in vitro. |
| Keywords: | D-Glucosamine Hydroehloride lymphoeytes proliferation IL-2 anti-tumour |
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