| 氯诺昔康凝胶的制备及质量控制 |
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| 引用本文： | 王薇,刘祖雄,覃贝,李强. 氯诺昔康凝胶的制备及质量控制[J]. 中国药房, 2007, 18(31): 2441-2442 |
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| 作者姓名： | 王薇 刘祖雄 覃贝 李强 |
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| 作者单位： | 广州军区武汉总医院药剂科,武汉市,430070 |
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| 摘 要： | 目的:制备氯诺昔康凝胶并建立其质量控制方法。方法:以壳聚糖为辅料制备凝胶;采用高效液相色谱法测定其中主药的含量,并采用加速试验、离心法考察其稳定性。结果:所制制剂涂展性好;氯诺昔康检测浓度的线性范围为12.5～125.0μg·mL-1,平均回收率为100.02%(RSD=1.18%) ;稳定性指标均符合规定。结论:本制剂制备工艺简单,质量稳定、可控。
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| 关 键 词： | 氯诺昔康凝胶 制备 质量控制 高效液相色谱法 |
| 文章编号： | 1001-0408（2007）31-2441-02 |
| 收稿时间： | 2007-01-22 |
| 修稿时间： | 2007-05-14 |
Preparation and Quality Control of Lornoxicam Gel |
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| WANG Wei,LIU Zuxiong,QIN Bei,LI Qiang. Preparation and Quality Control of Lornoxicam Gel[J]. China Pharmacy, 2007, 18(31): 2441-2442 |
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| Authors: | WANG Wei LIU Zuxiong QIN Bei LI Qiang |
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| Abstract: | OBJECTIVE: To prepare lornoxicam chitosan gel and to study its quality control method. METHODS: Lornoxicam chitosan gel was prepared with chitosan as excipient. The content of lornoxicam was determined by HPLC. The stability of the preparation was studied by accelerated test and centrifugation. RESULTS: The prepared gel was well-spread, with linear range at 12.5～125.0μg·mL-1 and average recovery at 100.02%(RSD=1.18%). The indexes of stability all met the standard. CONCLUSION: The preparing technology of lornoxicam chitosan gel is simple, and its quality is stable reliable. |
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| Keywords: | Lornoxicam gel Preparation Quality control HPLC |
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